Findings

What do systematic reviews say?

7 questions · 7 findings · 1 reviews · Epilepsy

Sort:Best matchNewest Highest certainty Download CSV

No studies found 0 · 0%GRADE not reported 0 · 0%Very low 0 · 0%Low 2 · 28.6%Moderate 3 · 42.9%High 2 · 28.6%

Modafinil vs placebo

Epworth Sleepiness Scale (ESS), week 3№ of participants: 101(2 RCTs) · idiopathic hypersomnia

1 finding from 1 review

Medications for daytime sleepiness in individuals with idiopathic hypersomnia 2021 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
High

Modafinil vs placebo

Number of naps/week, week 3№ of participants: 99(2 RCTs) · idiopathic hypersomnia

1 finding from 1 review

Medications for daytime sleepiness in individuals with idiopathic hypersomnia 2021 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
Low

Modafinil vs placebo

Clinical Global Impression ‐ Severity (CGI‐S), change from baseline№ of participants: 30(1 RCT) · idiopathic hypersomnia

1 finding from 1 review

Medications for daytime sleepiness in individuals with idiopathic hypersomnia 2021 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
Moderate

Modafinil vs placebo

Clinical Global Impression ‐ Change (CGI‐C), proportion much improved or very much improved at week 3 № of participants: 70 (1 RCT) · idiopathic hypersomnia

Modafinil probably leads to higher clinical Global Impression ‐ Change (CGI‐C), proportion much… compared with placebo (moderate certainty).

1 finding from 1 review

Medications for daytime sleepiness in individuals with idiopathic hypersomnia 2021 · Cochrane Headline outcomes only
OR 5.14 [1.76, 15]
Studies not reported
Moderate

Modafinil vs placebo

improvement in the maintenance of wakefulness test · idiopathic hypersomnia

1 finding from 1 review

Medications for daytime sleepiness in individuals with idiopathic hypersomnia 2021 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
High

Modafinil vs placebo

Effectiveness · idiopathic hypersomnia

1 finding from 1 review

Medications for daytime sleepiness in individuals with idiopathic hypersomnia 2021 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
Moderate

Modafinil vs placebo

Number of participants with any adverse events№ of participants: 102(2 RCTs) · idiopathic hypersomnia

Modafinil showed no clear difference in number of participants with any adverse events№ of participants:… compared with placebo (low certainty).

1 finding from 1 review

Medications for daytime sleepiness in individuals with idiopathic hypersomnia 2021 · Cochrane Headline outcomes only
OR 1.68 [0.28, 9.94]
Studies not reported
Low