What do systematic reviews say?

Vaginal misoprostol vs surgical evacuation of uterus

• Medical treatment for early fetal death (less than 24 weeks) 2019 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 50 participants
  Low

Misoprostol vs expectant care

It is very uncertain whether misoprostol changes complete miscarriage compared with expectant care (very low certainty).

• Medical treatments for incomplete miscarriage 2017 · Cochrane Headline outcomes only
  RR 1.23 [0.72, 2.1]
  2 studies · 150 participants
  Very low

Misoprostol vs surgery

Misoprostol may leads to higher unplanned surgical intervention compared with surgery (low certainty).

• Medical treatments for incomplete miscarriage 2017 · Cochrane Headline outcomes only
  RR 5.03 [2.71, 9.35]
  11 studies · 2690 participants
  Low

Misoprostol vs surgery

Misoprostol showed no clear difference in women's views/acceptability of method compared with surgery (moderate certainty).

• Medical treatments for incomplete miscarriage 2017 · Cochrane Headline outcomes only
  RR 1 [0.99, 1]
  9 studies · 3349 participants
  Moderate

Misoprostol vs surgery

Misoprostol may leads to higher nausea compared with surgery (low certainty).

• Medical treatments for incomplete miscarriage 2017 · Cochrane Headline outcomes only
  RR 2.5 [1.53, 4.09]
  11 studies · 3015 participants
  Low

Misoprostol vs surgery

Misoprostol probably leads to higher vomiting compared with surgery (moderate certainty).

• Medical treatments for incomplete miscarriage 2017 · Cochrane Headline outcomes only
  RR 1.97 [1.36, 2.85]
  10 studies · 2977 participants
  Moderate

Misoprostol vs surgery

Misoprostol probably leads to higher diarrhoea compared with surgery (moderate certainty).

• Medical treatments for incomplete miscarriage 2017 · Cochrane Headline outcomes only
  RR 4.82 [1.09, 21.32]
  4 studies · 757 participants
  Moderate

Misoprostol vs expectant care

Misoprostol showed no clear difference in surgical evacuation compared with expectant care (low certainty).

• Medical treatments for incomplete miscarriage 2017 · Cochrane Headline outcomes only
  RR 0.62 [0.17, 2.26]
  2 studies · 308 participants
  Low

Misoprostol vs expectant care

Misoprostol showed no clear difference in unplanned surgical intervention compared with expectant care (low certainty).

• Medical treatments for incomplete miscarriage 2017 · Cochrane Headline outcomes only
  RR 0.62 [0.17, 2.26]
  2 studies · 308 participants
  Low

Misoprostol vs expectant care

• Medical treatments for incomplete miscarriage 2017 · Cochrane Headline outcomes only
  no estimate extracted
  0 studies · 0 participants
  GRADE not reported

Misoprostol vs expectant care

• Medical treatments for incomplete miscarriage 2017 · Cochrane Headline outcomes only
  no estimate extracted
  0 studies · 0 participants
  GRADE not reported

Misoprostol vs expectant care

• Medical treatments for incomplete miscarriage 2017 · Cochrane Headline outcomes only
  no estimate extracted
  0 studies · 0 participants
  GRADE not reported

Misoprostol vs expectant care

• Medical treatments for incomplete miscarriage 2017 · Cochrane Headline outcomes only
  no estimate extracted
  0 studies · 0 participants
  GRADE not reported

Misoprostol vs surgery

It is very uncertain whether misoprostol changes complete miscarriage compared with surgery (very low certainty).

• Medical treatments for incomplete miscarriage 2017 · Cochrane Headline outcomes only
  RR 0.96 [0.94, 0.98]
  15 studies · 3862 participants
  Very low

Misoprostol vs surgery

It is very uncertain whether misoprostol changes surgical evacuation compared with surgery (very low certainty).

• Medical treatments for incomplete miscarriage 2017 · Cochrane Headline outcomes only
  RR 0.05 [0.02, 0.11]
  13 studies · 3070 participants
  Very low

Vaginal misoprostol vs placebo

Vaginal misoprostol may leads to higher complete miscarriage compared with placebo (low certainty).

• Medical treatment for early fetal death (less than 24 weeks) 2019 · Cochrane Headline outcomes only
  RR 4.23 [3.01, 5.94]
  5 studies · 305 participants
  Low

Vaginal misoprostol vs surgical evacuation of uterus

Vaginal misoprostol may leads to higher nausea compared with surgical evacuation of uterus (low certainty).

• Medical treatment for early fetal death (less than 24 weeks) 2019 · Cochrane Headline outcomes only
  RR 21.85 [1.31, 364.37]
  1 study · 154 participants
  Low

Vaginal misoprostol vs surgical evacuation of uterus

Vaginal misoprostol may leads to higher diarrhoea compared with surgical evacuation of uterus (low certainty).

• Medical treatment for early fetal death (less than 24 weeks) 2019 · Cochrane Headline outcomes only
  RR 40.85 [2.52, 662.57]
  1 study · 154 participants
  Low

Vaginal misoprostol vs surgical evacuation of uterus

Vaginal misoprostol may leads to higher pain relief compared with surgical evacuation of uterus (low certainty).

• Medical treatment for early fetal death (less than 24 weeks) 2019 · Cochrane Headline outcomes only
  RR 1.42
  1 study · 154 participants
  Low

Vaginal misoprostol vs surgical evacuation of uterus

Vaginal misoprostol showed no clear difference in woman’s satisfaction/acceptability of method compared with surgical evacuation of uterus (low certainty).

• Medical treatment for early fetal death (less than 24 weeks) 2019 · Cochrane Headline outcomes only
  RR 0.67 [0.4, 1.11]
  1 study · 45 participants
  Low