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What do systematic reviews say?

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Evidence found and GRADE certainty

7 questions · 7 findings · 1 reviews · Pain, Palliative and Supportive Care

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No studies found 0 · 0%GRADE not reported 0 · 0%Very low 1 · 14.3%Low 6 · 85.7%Moderate 0 · 0%High 0 · 0%

Mirtazapine vs placebo

Participant‐reported pain relief of 50% or greater · adults with fibromyalgia

Mirtazapine showed no clear difference in participant‐reported pain relief of 50% or greater (substantial… compared with placebo (low certainty).

1 finding from 1 review

Mirtazapine vs placebo

Safety Any serious adverse event · adults with fibromyalgia

It is very uncertain whether mirtazapine changes safety: serious adverse events compared with placebo (very low certainty).

1 finding from 1 review

Mirtazapine vs placebo

Withdrawals due to adverse events · adults with fibromyalgia

Mirtazapine showed no clear difference in tolerability: withdrawals due to adverse events compared with placebo (low certainty).

1 finding from 1 review

Mirtazapine vs placebo

Participant‐reported pain relief of 30% or greater · adults with fibromyalgia

Mirtazapine may leads to higher participant‐reported pain relief of 30% or greater (moderate… compared with placebo (low certainty).

1 finding from 1 review

Mirtazapine vs placebo

Participant‐reported sleep problems (scale: 0 to 28; higher scores indicate more sleep problems) · adults with fibromyalgia

Mirtazapine showed no clear difference in participant‐reported sleep problems (scale: 0 to 28; higher scores… compared with placebo (low certainty).

1 finding from 1 review