Findings

What do systematic reviews say?

12 questions · 13 findings · 1 reviews · Airways

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No studies found 0 · 0%GRADE not reported 0 · 0%Very low 1 · 7.7%Low 8 · 61.5%Moderate 3 · 23.1%High 1 · 7.7%

MgSO4 + SABA vs SABA

PEF (L/min) · adults and children with acute exacerbation of asthma

2 findings from 1 review

Inhaled magnesium sulfate in the treatment of acute asthma 2017 · Cochrane Headline outcomes only
no estimate extracted
1 study · 80 participants
Low
Inhaled magnesium sulfate in the treatment of acute asthma 2017 · Cochrane Headline outcomes only
no estimate extracted
3 studies · 155 participants
Low

MgSO4 + SABA vs SABA

Admission to hospital at initial presentation · adults and children with acute exacerbation of asthma

MgSO4 + SABA showed no clear difference in admission to hospital at initial presentation compared with SABA (low certainty).

1 finding from 1 review

Inhaled magnesium sulfate in the treatment of acute asthma 2017 · Cochrane Headline outcomes only
RR 0.78 [0.52, 1.15]
6 studies · 375 participants
Low

MgSO4 + SABA vs SABA

Serious adverse events (During ED/hospital admission) · adults and children with acute exacerbation of asthma

1 finding from 1 review

Inhaled magnesium sulfate in the treatment of acute asthma 2017 · Cochrane Headline outcomes only
no estimate extracted
5 studies · 243 participants
Low

MgSO4 + SABA vs SABA

Any adverse events (During ED/hospital admission) · adults and children with acute exacerbation of asthma

1 finding from 1 review

Inhaled magnesium sulfate in the treatment of acute asthma 2017 · Cochrane Headline outcomes only
no estimate extracted
5 studies · 694 participants
Low

MgSO4 + SABA vs SABA

FEV1 % predicted · adults and children with acute exacerbation of asthma

1 finding from 1 review

Inhaled magnesium sulfate in the treatment of acute asthma 2017 · Cochrane Headline outcomes only
no estimate extracted
4 studies · 208 participants
Low

MgSO4 + SABA + ipratropium vs SABA + ipratropium

FEV1 · adults and children with acute exacerbation of asthma

1 finding from 1 review

Inhaled magnesium sulfate in the treatment of acute asthma 2017 · Cochrane Headline outcomes only
no estimate extracted
2 studies · 120 participants
Very low

MgSO4 + SABA + ipratropium vs SABA + ipratropium

Pulmonary function % predicted PEF (60 minutes) · adults and children with acute exacerbation of asthma

1 finding from 1 review

Inhaled magnesium sulfate in the treatment of acute asthma 2017 · Cochrane Headline outcomes only
no estimate extracted
2 studies · 636 participants
Moderate

MgSO4 + SABA + ipratropium vs SABA + ipratropium

Clinical severity scores (60 minutes) · adults and children with acute exacerbation of asthma

1 finding from 1 review

Inhaled magnesium sulfate in the treatment of acute asthma 2017 · Cochrane Headline outcomes only
no estimate extracted
2 studies · 1130 participants
Low

MgSO4 + SABA + ipratropium vs SABA + ipratropium

Admission to hospital at initial presentation · adults and children with acute exacerbation of asthma

MgSO4 + SABA + ipratropium showed no clear difference in admission at first presentation compared with SABA + ipratropium (moderate certainty).

1 finding from 1 review

Inhaled magnesium sulfate in the treatment of acute asthma 2017 · Cochrane Headline outcomes only
RR 0.95 [0.91, 1]
4 studies · 1308 participants
Moderate

MgSO4 + SABA + ipratropium vs SABA + ipratropium

Patient readmissions · adults and children with acute exacerbation of asthma

MgSO4 + SABA + ipratropium showed no clear difference in readmission (7 to 30 days) compared with SABA + ipratropium (low certainty).

1 finding from 1 review

Inhaled magnesium sulfate in the treatment of acute asthma 2017 · Cochrane Headline outcomes only
RR 1.8 [0.84, 3.87]
2 studies · 750 participants
Low

MgSO4 + SABA + ipratropium vs SABA + ipratropium

Serious adverse events (during admission) · adults and children with acute exacerbation of asthma

1 finding from 1 review

Inhaled magnesium sulfate in the treatment of acute asthma 2017 · Cochrane Headline outcomes only
no estimate extracted
2 studies · 557 participants
Moderate

MgSO4 + SABA + ipratropium vs SABA + ipratropium

Adverse effects Defined as any adverse event occurring post‐admission · adults and children with acute exacerbation of asthma

1 finding from 1 review

Inhaled magnesium sulfate in the treatment of acute asthma 2017 · Cochrane Headline outcomes only
no estimate extracted
2 studies · 1197 participants
High