Findings

What do systematic reviews say?

3 questions · 7 findings · 1 reviews

No studies found 0 · 0%GRADE not reported 6 · 85.7%Very low 1 · 14.3%Low 0 · 0%Moderate 0 · 0%High 0 · 0%

Probing pocket depth · Adults with periodontitis (chronic and aggressive)

Amoxicillin + metronidazole + SRP led to lower probing pocket depth compared with SRP; GRADE not reported.

3 findings from 1 review

Adjunctive systemic antimicrobials for the non‐surgical treatment of periodontitis 2020 · Cochrane All outcomes
Intermediate-term (> 3 months to < 1 year)
MD -0.47 [-0.68, -0.26]
6 studies · 215 participants
GRADE not reported
Adjunctive systemic antimicrobials for the non‐surgical treatment of periodontitis 2020 · Cochrane All outcomes
Short-term (≤ 3 months)
MD -0.18 [-0.33, -0.04]
15 studies · 562 participants
GRADE not reported
Adjunctive systemic antimicrobials for the non‐surgical treatment of periodontitis 2020 · Cochrane All outcomes
Long-term (≥ 1 year)
MD -0.30 [-0.42, -0.18]
2 studies · 389 participants
Very low

Probing pocket depth · Adults with aggressive periodontitis

Amoxicillin + metronidazole + SRP led to lower probing pocket depth compared with clarithromycin + SRP; GRADE not reported.

2 findings from 1 review

Adjunctive systemic antimicrobials for the non‐surgical treatment of periodontitis 2020 · Cochrane All outcomes
Short-term (≤ 3 months)
MD -0.20 [-0.35, -0.05]
1 study · 46 participants
GRADE not reported
Adjunctive systemic antimicrobials for the non‐surgical treatment of periodontitis 2020 · Cochrane All outcomes
Intermediate-term (> 3 months to < 1 year)
MD -0.10 [-0.26, 0.06]
1 study · 46 participants
GRADE not reported

Probing pocket depth · Adults with periodontitis (chronic and aggressive)

Metronidazole + SRP showed no clear difference in probing pocket depth compared with amoxicillin + metronidazole + SRP; GRADE not reported.

2 findings from 1 review

Adjunctive systemic antimicrobials for the non‐surgical treatment of periodontitis 2020 · Cochrane All outcomes
Intermediate-term (> 3 months to < 1 year)
MD -0.26 [-0.83, 0.31]
1 study · 22 participants
GRADE not reported
Adjunctive systemic antimicrobials for the non‐surgical treatment of periodontitis 2020 · Cochrane All outcomes
Short-term (≤ 3 months)
MD 0.10 [-0.12, 0.32]
3 studies · 84 participants
GRADE not reported