Findings

What do systematic reviews say?

5 questions · 5 findings · 2 reviews

Sort:Best matchNewest Highest certainty Download CSV

No studies found 0 · 0%GRADE not reported 2 · 40%Very low 3 · 60%Low 0 · 0%Moderate 0 · 0%High 0 · 0%

Metronidazole + SRP vs Amoxicillin + metronidazole + SRP

Adverse events · Adults with periodontitis (chronic and aggressive)

Metronidazole + SRP showed no clear difference in adverse events compared with amoxicillin + metronidazole + SRP; GRADE not reported.

1 finding from 1 review

Adjunctive systemic antimicrobials for the non‐surgical treatment of periodontitis 2020 · Cochrane All outcomes
All three included trials (Matarazzo 2008; Silva 2011; Xajigeorgiou 2006) reported adverse events in both MTZ + SRP and AMOX + MTZ + SRP groups (nausea, vomiting, diarrhoea, headache, metallic taste, irritability, mild…
3 studies · 84 participants
GRADE not reported

Metronidazole + SRP vs SRP

Adverse events · Adults with periodontitis (chronic and aggressive)

It is very uncertain whether metronidazole + SRP changes adverse events compared with SRP (very low certainty).

1 finding from 1 review

Adjunctive systemic antimicrobials for the non‐surgical treatment of periodontitis 2020 · Cochrane All outcomes
Long-term (≥ 1 year)
No severe adverse effects were reported by any of the participants in 1 study. 2 studies have not reported adverse events.
3 studies · 71 participants
Very low

Amoxicillin + metronidazole + SRP vs Clarithromycin + SRP

Adverse events · Adults with aggressive periodontitis

Amoxicillin + metronidazole + SRP showed no clear difference in adverse events compared with clarithromycin + SRP; GRADE not reported.

1 finding from 1 review

Adjunctive systemic antimicrobials for the non‐surgical treatment of periodontitis 2020 · Cochrane All outcomes
Two patients were reported to have vomiting and unbearable stomach pain in the AMOX + MTZ + SRP group (Araujo 2019).
1 study
GRADE not reported

Amoxicillin + metronidazole + SRP vs SRP

Adverse events · Adults with periodontitis (chronic and aggressive)

It is very uncertain whether amoxicillin + metronidazole + SRP changes adverse events compared with SRP (very low certainty).

1 finding from 1 review

Adjunctive systemic antimicrobials for the non‐surgical treatment of periodontitis 2020 · Cochrane All outcomes
Long-term (≥ 1 year)
Most common adverse events were mild gastrointestinal disturbances, nausea and vomiting, metallic taste, and diarrhoea in the intervention group. Control group reported adverse events like hypothermia, mild…
2 studies · 389 participants
Very low

Amoxicillin + metronidazole + SRP vs Supragingival scaling (plus placebo)

Adverse events due to periodontal therapy · People with periodontitis and metabolic syndrome (no CVD; primary prevention)

It is very uncertain whether scaling and root planing (SRP) plus antibiotics (amoxicillin and… changes adverse events due to periodontal therapy compared with supragingival scaling (plus placebo) (very low certainty).

1 finding from 1 review

Periodontal therapy for primary or secondary prevention of cardiovascular disease in people with periodontitis 2022 · Cochrane All outcomes
12 months
Peto OR 0.14 [0.00, 6.90]
1 study · 165 participants
Very low