evidencegaps
Findings

What do systematic reviews say?

Refine by population, intervention, comparison or outcome
More filters
Evidence found and GRADE certainty

15 questions · 15 findings · 2 reviews · Musculoskeletal

Sort:Best matchNewestHighest certaintyDownload CSV
No studies found 5 · 33.3%GRADE not reported 0 · 0%Very low 0 · 0%Low 10 · 66.7%Moderate 0 · 0%High 0 · 0%

Methotrexate vs placebo

Treatment responsea · children and young people with JIA

Methotrexate may leads to higher treatment responsea(up to 6 months) compared with placebo (low certainty).

1 finding from 1 review

Methotrexate vs placebo

Global well‐being: rated by participants · children and young people with JIA

Methotrexate showed no clear difference in participant global assessment of well‐being(up to 6 months) compared with placebo (low certainty).

1 finding from 1 review

Methotrexate vs placebo

Serious adverse events(up to 6 months) · children and young people with JIA

Methotrexate showed no clear difference in serious adverse events(up to 6 months) compared with placebo (low certainty).

1 finding from 1 review

Methotrexate vs placebo

Withdrawals due to adverse events · children and young people with JIA

Methotrexate showed no clear difference in withdrawals due to adverse events (up to 6 months) compared with placebo (low certainty).

1 finding from 1 review

Methotrexate vs placebo

Disease response · psoriatic arthritis

Methotrexate may leads to higher disease response compared with placebo (low certainty).

1 finding from 1 review

Methotrexate vs placebo

Health‐related quality of life ‐ not reported · psoriatic arthritis

The review found no eligible studies for this question.

1 finding from 1 review

Methotrexate vs placebo

Change in radiographic progression ‐ not measured · psoriatic arthritis

The review found no eligible studies for this question.

1 finding from 1 review

Methotrexate vs placebo

SAEs · psoriatic arthritis

Methotrexate showed no clear difference in serious adverse events (SAEs) assessed by number of events compared with placebo (low certainty).

1 finding from 1 review

Methotrexate vs placebo

Withdrawals due to adverse events · psoriatic arthritis

Methotrexate showed no clear difference in withdrawals due to adverse events (WAEs) assessed by number of events compared with placebo (low certainty).

1 finding from 1 review