evidencegaps
Findings

What do systematic reviews say?

Refine by population, intervention, comparison or outcome
More filters
Evidence found and GRADE certainty

51 questions · 52 findings · 4 reviews · Musculoskeletal

Sort:Best matchNewestHighest certaintyDownload CSV
No studies found 17 · 32.7%GRADE not reported 0 · 0%Very low 7 · 13.5%Low 17 · 32.7%Moderate 6 · 11.5%High 5 · 9.6%

Methotrexate vs placebo

Treatment responsea · children and young people with JIA

Methotrexate may leads to higher treatment responsea(up to 6 months) compared with placebo (low certainty).

1 finding from 1 review

Methotrexate vs placebo

Global well‐being: rated by participants · children and young people with JIA

Methotrexate showed no clear difference in participant global assessment of well‐being(up to 6 months) compared with placebo (low certainty).

1 finding from 1 review

Methotrexate vs placebo

Serious adverse events(up to 6 months) · children and young people with JIA

Methotrexate showed no clear difference in serious adverse events(up to 6 months) compared with placebo (low certainty).

1 finding from 1 review

Methotrexate vs placebo

Withdrawals due to adverse events · children and young people with JIA

Methotrexate showed no clear difference in withdrawals due to adverse events (up to 6 months) compared with placebo (low certainty).

1 finding from 1 review

Methotrexate vs placebo

Disease response · psoriatic arthritis

Methotrexate may leads to higher disease response compared with placebo (low certainty).

1 finding from 1 review