What do systematic reviews say?

5 questions · 10 findings · 2 reviews · Gynaecology and Fertility · asked by two or more reviews

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No studies found 0 · 0%GRADE not reported 0 · 0%Very low 0 · 0%Low 5 · 50%Moderate 5 · 50%High 0 · 0%

Metformin combined with clomiphene citrate vs clomiphene

Miscarriage · women with polycystic ovary syndrome

Metformin combined with clomiphene citrate showed no clear difference in miscarriage rate per woman compared with clomiphene citrate alone (low certainty).

2 findings from 2 reviews · compare the 2 reviews

Metformin for ovulation induction (excluding gonadotrophins) in women with polycystic ovary syndrome 2019 · Cochrane Headline outcomes only
OR 1.35 [0.91, 2]
10 studies · 1206 participants
Low
Insulin‐sensitising drugs (metformin, rosiglitazone, pioglitazone, D‐chiro‐inositol) for women with polycystic ovary… 2017 · Cochrane Headline outcomes only
OR 1.59 [1.03, 2.46]
9 studies · 1096 participants
Low

Metformin combined with clomiphene citrate vs clomiphene

Live birth rate per woman · women with polycystic ovary syndrome

Metformin combined with clomiphene citrate showed no clear difference in live birth rate per woman compared with clomiphene citrate alone (low certainty).

2 findings from 2 reviews · compare the 2 reviews

Metformin for ovulation induction (excluding gonadotrophins) in women with polycystic ovary syndrome 2019 · Cochrane Headline outcomes only
OR 1.27 [0.98, 1.65]
10 studies · 1219 participants
Low
Insulin‐sensitising drugs (metformin, rosiglitazone, pioglitazone, D‐chiro‐inositol) for women with polycystic ovary… 2017 · Cochrane Headline outcomes only
OR 1.21 [0.92, 1.59]
9 studies · 1079 participants
Low

Metformin combined with clomiphene citrate vs clomiphene

Gastrointestinal adverse events · women with polycystic ovary syndrome

Metformin combined with clomiphene citrate probably leads to higher adverse events (gastrointestinal) per woman compared with clomiphene citrate alone (moderate certainty).

2 findings from 2 reviews · compare the 2 reviews

Metformin for ovulation induction (excluding gonadotrophins) in women with polycystic ovary syndrome 2019 · Cochrane Headline outcomes only
OR 4.26 [2.83, 6.4]
6 studies · 852 participants
Moderate
Insulin‐sensitising drugs (metformin, rosiglitazone, pioglitazone, D‐chiro‐inositol) for women with polycystic ovary… 2017 · Cochrane Headline outcomes only
OR 3.97 [2.59, 6.08]
3 studies · 591 participants
Moderate

Metformin combined with clomiphene citrate vs clomiphene

Clinical pregnancy rate · women with polycystic ovary syndrome

Metformin combined with clomiphene citrate probably leads to higher clinical pregnancy rate per woman compared with clomiphene citrate alone (moderate certainty).

2 findings from 2 reviews · compare the 2 reviews

Metformin for ovulation induction (excluding gonadotrophins) in women with polycystic ovary syndrome 2019 · Cochrane Headline outcomes only
OR 1.62 [1.32, 1.99]
19 studies · 1790 participants
Moderate
Insulin‐sensitising drugs (metformin, rosiglitazone, pioglitazone, D‐chiro‐inositol) for women with polycystic ovary… 2017 · Cochrane Headline outcomes only
OR 1.59 [1.27, 1.99]
16 studies · 1529 participants
Moderate

Metformin combined with clomiphene citrate vs clomiphene

Ovulation rate · women with polycystic ovary syndrome

Metformin combined with clomiphene citrate may leads to higher ovulation rate per woman compared with clomiphene citrate alone (low certainty).

2 findings from 2 reviews · compare the 2 reviews

Metformin for ovulation induction (excluding gonadotrophins) in women with polycystic ovary syndrome 2019 · Cochrane Headline outcomes only
OR 1.65 [1.35, 2.03]
22 studies · 1601 participants
Low
Insulin‐sensitising drugs (metformin, rosiglitazone, pioglitazone, D‐chiro‐inositol) for women with polycystic ovary… 2017 · Cochrane Headline outcomes only
OR 1.57 [1.28, 1.92]
21 studies · 1624 participants
Moderate