Findings

What do systematic reviews say?

6 questions · 6 findings · 1 reviews · Gynaecology and Fertility

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No studies found 1 · 16.7%GRADE not reported 0 · 0%Very low 0 · 0%Low 2 · 33.3%Moderate 3 · 50%High 0 · 0%

Metformin combined with clomiphene citrate vs clomiphene

Menstrual frequency per woman · women with polycystic ovary syndrome

The review found no eligible studies for this question.

1 finding from 1 review

Insulin‐sensitising drugs (metformin, rosiglitazone, pioglitazone, D‐chiro‐inositol) for women with polycystic ovary… 2017 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Metformin combined with clomiphene citrate vs clomiphene

Ovulation rate · women with polycystic ovary syndrome

Metformin combined with clomiphene citrate probably leads to higher ovulation rate per woman compared with clomiphene citrate alone (moderate certainty).

1 finding from 1 review · compare the 2 reviews

Insulin‐sensitising drugs (metformin, rosiglitazone, pioglitazone, D‐chiro‐inositol) for women with polycystic ovary… 2017 · Cochrane Headline outcomes only
OR 1.57 [1.28, 1.92]
21 studies · 1624 participants
Moderate

Metformin combined with clomiphene citrate vs clomiphene

Miscarriage · women with polycystic ovary syndrome

Metformin combined with clomiphene citrate may leads to higher miscarriage rate per woman compared with clomiphene citrate alone (low certainty).

1 finding from 1 review · compare the 2 reviews

Insulin‐sensitising drugs (metformin, rosiglitazone, pioglitazone, D‐chiro‐inositol) for women with polycystic ovary… 2017 · Cochrane Headline outcomes only
OR 1.59 [1.03, 2.46]
9 studies · 1096 participants
Low

Metformin combined with clomiphene citrate vs clomiphene

Live birth rate per woman · women with polycystic ovary syndrome

Metformin combined with clomiphene citrate showed no clear difference in live birth rate per woman compared with clomiphene citrate alone (low certainty).

1 finding from 1 review · compare the 2 reviews

Insulin‐sensitising drugs (metformin, rosiglitazone, pioglitazone, D‐chiro‐inositol) for women with polycystic ovary… 2017 · Cochrane Headline outcomes only
OR 1.21 [0.92, 1.59]
9 studies · 1079 participants
Low

Metformin combined with clomiphene citrate vs clomiphene

Gastrointestinal adverse events · women with polycystic ovary syndrome

Metformin combined with clomiphene citrate probably leads to higher adverse events (gastrointestinal) per woman compared with clomiphene citrate alone (moderate certainty).

1 finding from 1 review · compare the 2 reviews

Insulin‐sensitising drugs (metformin, rosiglitazone, pioglitazone, D‐chiro‐inositol) for women with polycystic ovary… 2017 · Cochrane Headline outcomes only
OR 3.97 [2.59, 6.08]
3 studies · 591 participants
Moderate

Metformin combined with clomiphene citrate vs clomiphene

Clinical pregnancy rate · women with polycystic ovary syndrome

Metformin combined with clomiphene citrate probably leads to higher clinical pregnancy rate per woman compared with clomiphene citrate alone (moderate certainty).

1 finding from 1 review · compare the 2 reviews

Insulin‐sensitising drugs (metformin, rosiglitazone, pioglitazone, D‐chiro‐inositol) for women with polycystic ovary… 2017 · Cochrane Headline outcomes only
OR 1.59 [1.27, 1.99]
16 studies · 1529 participants
Moderate