Findings

What do systematic reviews say?

2 questions · 4 findings · 2 reviews · asked by two or more reviews

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No studies found 0 · 0%GRADE not reported 0 · 0%Very low 1 · 25%Low 2 · 50%Moderate 1 · 25%High 0 · 0%

Metformin vs placebo or no treatment

Clinical pregnancy rate · women with polycystic ovary syndrome

It is very uncertain whether metformin changes clinical pregnancy rate per woman ‐ short protocol GnRH‐antagonist compared with placebo or no treatment (very low certainty).

2 findings from 2 reviews · compare the 2 reviews

Metformin treatment before and during IVF or ICSI in women with polycystic ovary syndrome 2020 · Cochrane Headline outcomes only
RR 1.38 [0.21, 9.14]
2 studies · 177 participants
Very low
Metformin for ovulation induction (excluding gonadotrophins) in women with polycystic ovary syndrome 2019 · Cochrane Headline outcomes only
OR 1.98 [1.47, 2.65]
11 studies · 1213 participants
Moderate

Metformin vs placebo or no treatment

Miscarriage · women with polycystic ovary syndrome

Metformin showed no clear difference in miscarriage rate per woman compared with placebo or no treatment (low certainty).

2 findings from 2 reviews · compare the 2 reviews

Metformin treatment before and during IVF or ICSI in women with polycystic ovary syndrome 2020 · Cochrane Headline outcomes only
RR 0.86 [0.56, 1.32]
8 studies · 821 participants
Low
Metformin for ovulation induction (excluding gonadotrophins) in women with polycystic ovary syndrome 2019 · Cochrane Headline outcomes only
OR 1.08 [0.5, 2.35]
4 studies · 748 participants
Low