Metformin showed no clear difference in live birth rate per woman compared with placebo or no treatment (low certainty).
It is very uncertain whether metformin changes live birth rate per woman aParticipants with BMI < 30 kg/m2 or ≤ 32… compared with clomiphene citrate (very low certainty).
It is very uncertain whether metformin changes live birth rate per woman aParticipants with BMI ≥ 30 kg/m2 compared with clomiphene citrate (very low certainty).
The review found no eligible studies for this question.
Metformin may leads to higher clinical pregnancy rate per womanaParticipants with BMI < 30 kg/m2… compared with clomiphene citrate (low certainty).
Metformin may leads to lower clinical pregnancy rate per woman aParticipants with BMI ≥ 30 kg/m2 compared with clomiphene citrate (low certainty).
Metformin showed no clear difference in ovulation rate per woman fParticipants with BMI < 30 kg/m2 compared with clomiphene citrate (low certainty).
Metformin may leads to lower ovulation rate per woman fParticipants with BMI ≥ 30 kg/m2 compared with clomiphene citrate (low certainty).
Metformin showed no clear difference in miscarriage rate per woman aParticipants with BMI < 30 kg/2 compared with clomiphene citrate (low certainty).
Metformin showed no clear difference in miscarriage rate per woman aParticipants with BMI ≥ 30 kg/m2 compared with clomiphene citrate (low certainty).
Metformin probably leads to higher adverse events (gastrointestinal) per woman compared with placebo or no treatment (moderate certainty).
Metformin probably leads to higher clinical pregnancy rate per woman compared with placebo or no treatment (moderate certainty).
Metformin may leads to higher ovulation rate per woman compared with placebo or no treatment (low certainty).
Metformin showed no clear difference in miscarriage rate per woman compared with placebo or no treatment (low certainty).
Metformin may leads to higher live birth rate (per woman) compared with placebo co‐treatment (low certainty).
Metformin showed no clear difference in multiple pregnancy rate (per woman) compared with placebo co‐treatment (low certainty).
Metformin may leads to higher ongoing pregnancy rate (per woman) compared with placebo co‐treatment (low certainty).
Metformin may leads to higher clinical pregnancy rate (per woman) compared with placebo co‐treatment (low certainty).
Metformin combined with clomiphene citrate showed no clear difference in miscarriage rate per woman compared with clomiphene citrate alone (low certainty).
Metformin combined with clomiphene citrate showed no clear difference in live birth rate per woman compared with clomiphene citrate alone (low certainty).