Findings

What do systematic reviews say?

4 questions · 4 findings · 1 reviews

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No studies found 0 · 0%GRADE not reported 0 · 0%Very low 0 · 0%Low 2 · 50%Moderate 2 · 50%High 0 · 0%

Metformin vs placebo or no treatment

Ovulation rate · Women with polycystic ovary syndrome, oligo amenorrhoea and subfertility

Metformin probably leads to higher ovulation rate per woman compared with placebo or no treatment (moderate certainty).

1 finding from 1 review

Insulin‐sensitising drugs (metformin, rosiglitazone, pioglitazone, D‐chiro‐inositol) for women with polycystic ovary… 2017 · Cochrane Headline outcomes only
OR 2.55 [1.81, 3.59]
14 studies · 701 participants
Moderate

Metformin vs clomiphene

Ovulation rate per woman fParticipants with BMI < 30 kg/m2 · women with polycystic ovary syndrome

Metformin showed no clear difference in ovulation rate per woman Participants with BMI < 30 kg/m2b compared with clomiphene citrate (low certainty).

1 finding from 1 review · compare the 2 reviews

Insulin‐sensitising drugs (metformin, rosiglitazone, pioglitazone, D‐chiro‐inositol) for women with polycystic ovary… 2017 · Cochrane Headline outcomes only
OR 0.81 [0.51, 1.28]
4 studies · 312 participants
Low

Metformin vs clomiphene

Ovulation rate per woman fParticipants with BMI ≥ 30 kg/m2 · women with polycystic ovary syndrome

Metformin may leads to lower ovulation rate per woman Participants with BMI ≥ 30 kg/m2b compared with clomiphene citrate (low certainty).

1 finding from 1 review · compare the 2 reviews

Insulin‐sensitising drugs (metformin, rosiglitazone, pioglitazone, D‐chiro‐inositol) for women with polycystic ovary… 2017 · Cochrane Headline outcomes only
OR 0.29 [0.2, 0.43]
2 studies · 500 participants
Low

Metformin combined with clomiphene citrate vs clomiphene

Ovulation rate · women with polycystic ovary syndrome

Metformin combined with clomiphene citrate probably leads to higher ovulation rate per woman compared with clomiphene citrate alone (moderate certainty).

1 finding from 1 review · compare the 2 reviews

Insulin‐sensitising drugs (metformin, rosiglitazone, pioglitazone, D‐chiro‐inositol) for women with polycystic ovary… 2017 · Cochrane Headline outcomes only
OR 1.57 [1.28, 1.92]
21 studies · 1624 participants
Moderate