Findings

What do systematic reviews say?

5 questions · 5 findings · 2 reviews

Sort:Best matchNewest Highest certainty Download CSV

No studies found 0 · 0%GRADE not reported 0 · 0%Very low 0 · 0%Low 3 · 60%Moderate 2 · 40%High 0 · 0%

Metformin vs placebo or no treatment

Clinical pregnancy rate · women with polycystic ovary syndrome

Metformin probably leads to higher clinical pregnancy rate per woman compared with placebo or no treatment (moderate certainty).

1 finding from 1 review · compare the 2 reviews

Metformin for ovulation induction (excluding gonadotrophins) in women with polycystic ovary syndrome 2019 · Cochrane Headline outcomes only
OR 1.98 [1.47, 2.65]
11 studies · 1213 participants
Moderate

Metformin vs placebo co‐treatment

Clinical pregnancy rate · subfertile women with polycystic ovary syndrome

Metformin may leads to higher clinical pregnancy rate (per woman) compared with placebo co‐treatment (low certainty).

1 finding from 1 review

Metformin during ovulation induction with gonadotrophins followed by timed intercourse or intrauterine insemination… 2017 · Cochrane Headline outcomes only
OR 2.51 [1.46, 4.31]
5 studies · 264 participants
Low

Metformin vs clomiphene

Clinical pregnancy rate per woman aParticipants with BMI ≥ 30 kg/m2 · women with polycystic ovary syndrome

Metformin may leads to lower clinical pregnancy rate per woman aParticipants with BMI ≥ 30 kg/m2 compared with clomiphene citrate (low certainty).

1 finding from 1 review · compare the 2 reviews

Metformin for ovulation induction (excluding gonadotrophins) in women with polycystic ovary syndrome 2019 · Cochrane Headline outcomes only
OR 0.34 [0.21, 0.55]
2 studies · 500 participants
Low

Metformin vs clomiphene

Clinical pregnancy rate per woman Participants with BMI < 30 kg/m2 or ≤ 32 kg/m2a · women with polycystic ovary syndrome

Metformin may leads to higher clinical pregnancy rate per womanaParticipants with BMI < 30 kg/m2… compared with clomiphene citrate (low certainty).

1 finding from 1 review · compare the 2 reviews

Metformin for ovulation induction (excluding gonadotrophins) in women with polycystic ovary syndrome 2019 · Cochrane Headline outcomes only
OR 1.56 [1.06, 2.29]
6 studies · 530 participants
Low

Metformin combined with clomiphene citrate vs clomiphene

Clinical pregnancy rate · women with polycystic ovary syndrome

Metformin combined with clomiphene citrate probably leads to higher clinical pregnancy rate per woman compared with clomiphene citrate alone (moderate certainty).

1 finding from 1 review · compare the 2 reviews

Metformin for ovulation induction (excluding gonadotrophins) in women with polycystic ovary syndrome 2019 · Cochrane Headline outcomes only
OR 1.62 [1.32, 1.99]
19 studies · 1790 participants
Moderate