Findings

What do systematic reviews say?

2 questions · 2 findings · 1 reviews

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No studies found 0 · 0%GRADE not reported 0 · 0%Very low 1 · 50%Low 1 · 50%Moderate 0 · 0%High 0 · 0%

Metformin vs placebo or no treatment

Clinical pregnancy rate per woman ‐ long protocol GnRH‐agonist · women with polycystic ovary syndrome

Metformin may leads to higher clinical pregnancy rate per woman ‐ long protocol GnRH‐agonist compared with placebo or no treatment (low certainty).

1 finding from 1 review

Metformin treatment before and during IVF or ICSI in women with polycystic ovary syndrome 2020 · Cochrane Headline outcomes only
RR 1.32 [1.08, 1.63]
10 studies · 915 participants
Low

Metformin vs placebo or no treatment

Clinical pregnancy rate · women with polycystic ovary syndrome

It is very uncertain whether metformin changes clinical pregnancy rate per woman ‐ short protocol GnRH‐antagonist compared with placebo or no treatment (very low certainty).

1 finding from 1 review · compare the 2 reviews

Metformin treatment before and during IVF or ICSI in women with polycystic ovary syndrome 2020 · Cochrane Headline outcomes only
RR 1.38 [0.21, 9.14]
2 studies · 177 participants
Very low