Findings

What do systematic reviews say?

5 questions · 8 findings · 1 reviews

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No studies found 0 · 0%GRADE not reported 0 · 0%Very low 4 · 50%Low 4 · 50%Moderate 0 · 0%High 0 · 0%

Memantine vs placebo

Efficacy: number of participants who respond to treatment ‐ at 3 months · adults (aged 18 years+) with depression in bipolar disorder

It is very uncertain whether memantine changes efficacy: number of participants who respond to treatment ‐ at 1 week compared with placebo (very low certainty).

4 findings from 1 review

Ketamine and other glutamate receptor modulators for depression in adults with bipolar disorder 2021 · Cochrane Headline outcomes only
OR 1.08 [0.06, 19.05]
1 study · 29 participants
Very low
Ketamine and other glutamate receptor modulators for depression in adults with bipolar disorder 2021 · Cochrane Headline outcomes only
OR 4.88 [0.78, 30.29]
1 study · 29 participants
Very low
Ketamine and other glutamate receptor modulators for depression in adults with bipolar disorder 2021 · Cochrane Headline outcomes only
OR 5.33 [1.02, 27.76]
1 study · 29 participants
Very low

Show 1 more finding

Ketamine and other glutamate receptor modulators for depression in adults with bipolar disorder 2021 · Cochrane Headline outcomes only
OR 1.66 [0.69, 4.03]
2 studies · 261 participants
Low

Memantine vs placebo

Remission · adults (aged 18 years+) with depression in bipolar disorder

It is very uncertain whether memantine changes efficacy: number of participants who achieve remission ‐ at 1 week compared with placebo (very low certainty).

1 finding from 1 review

Ketamine and other glutamate receptor modulators for depression in adults with bipolar disorder 2021 · Cochrane Headline outcomes only
OR 1.08 [0.06, 19.05]
1 study · 29 participants
Very low

Memantine vs placebo

Depressive symptoms · adults (aged 18 years+) with depression in bipolar disorder

1 finding from 1 review

Ketamine and other glutamate receptor modulators for depression in adults with bipolar disorder 2021 · Cochrane Headline outcomes only
no estimate extracted
1 study · 157 participants
Low

Memantine vs placebo

Acceptability ‐ total dropouts · adults (aged 18 years+) with depression in bipolar disorder

Memantine showed no clear difference in acceptability: total dropouts compared with placebo (low certainty).

1 finding from 1 review

Ketamine and other glutamate receptor modulators for depression in adults with bipolar disorder 2021 · Cochrane Headline outcomes only
OR 0.77 [0.45, 1.31]
2 studies · 261 participants
Low

Memantine vs placebo

Acceptability ‐ dropouts due to adverse effects · adults (aged 18 years+) with depression in bipolar disorder

Memantine showed no clear difference in acceptability: dropouts due to adverse effects compared with placebo (low certainty).

1 finding from 1 review

Ketamine and other glutamate receptor modulators for depression in adults with bipolar disorder 2021 · Cochrane Headline outcomes only
OR 0.34 [0.01, 8.34]
1 study · 232 participants
Low