Findings

What do systematic reviews say?

7 questions · 7 findings · 1 reviews · Schizophrenia

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No studies found 0 · 0%GRADE not reported 0 · 0%Very low 0 · 0%Low 3 · 42.9%Moderate 1 · 14.3%High 3 · 42.9%

Maintenance treatment with antipsychotic drugs vs placebo/no treatment

Relapse · schizophrenia

Maintenance treatment with antipsychotic drugs leads to lower relapse: 7 to 12 months compared with placebo/no treatment (high certainty).

1 finding from 1 review

Maintenance treatment with antipsychotic drugs for schizophrenia 2020 · Cochrane Headline outcomes only
RR 0.38 [0.32, 0.45]
30 studies · 4249 participants
High

Maintenance treatment with antipsychotic drugs vs placebo/no treatment

Acceptability of treatment ‐ leaving the study early · schizophrenia

Maintenance treatment with antipsychotic drugs leads to lower leaving the study early: due to any reason (acceptability of… compared with placebo/no treatment (high certainty).

1 finding from 1 review

Maintenance treatment with antipsychotic drugs for schizophrenia 2020 · Cochrane Headline outcomes only
RR 0.54 [0.49, 0.61]
56 studies · 7001 participants
High

Maintenance treatment with antipsychotic drugs vs placebo/no treatment

Service use: Number of participants hospitalised · schizophrenia

Maintenance treatment with antipsychotic drugs leads to lower service use: number of participants hospitalised compared with placebo/no treatment (high certainty).

1 finding from 1 review

Maintenance treatment with antipsychotic drugs for schizophrenia 2020 · Cochrane Headline outcomes only
RR 0.43 [0.32, 0.57]
21 studies · 3558 participants
High

Maintenance treatment with antipsychotic drugs vs placebo/no treatment

Death due to suicide · schizophrenia

Maintenance treatment with antipsychotic drugs showed no clear difference in death: due to suicide compared with placebo/no treatment (low certainty).

1 finding from 1 review

Maintenance treatment with antipsychotic drugs for schizophrenia 2020 · Cochrane Headline outcomes only
RR 0.6 [0.12, 2.97]
19 studies · 4634 participants
Low

Maintenance treatment with antipsychotic drugs vs placebo/no treatment

QoL · schizophrenia

1 finding from 1 review

Maintenance treatment with antipsychotic drugs for schizophrenia 2020 · Cochrane Headline outcomes only
no estimate extracted
7 studies · 1573 participants
Low

Maintenance treatment with antipsychotic drugs vs placebo/no treatment

Employment · schizophrenia

Maintenance treatment with antipsychotic drugs showed no clear difference in number of participants in employment compared with placebo/no treatment (low certainty).

1 finding from 1 review

Maintenance treatment with antipsychotic drugs for schizophrenia 2020 · Cochrane Headline outcomes only
RR 1.08 [0.82, 1.41]
3 studies · 593 participants
Low

Maintenance treatment with antipsychotic drugs vs placebo/no treatment

Social functioning · schizophrenia

1 finding from 1 review

Maintenance treatment with antipsychotic drugs for schizophrenia 2020 · Cochrane Headline outcomes only
no estimate extracted
15 studies · 3588 participants
Moderate