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What do systematic reviews say?

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Evidence found and GRADE certainty

31 questions · 31 findings · 2 reviews · Airways

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No studies found 8 · 25.8%GRADE not reported 0 · 0%Very low 3 · 9.7%Low 13 · 41.9%Moderate 7 · 22.6%High 0 · 0%

Macrolides vs placebo

Severe exacerbations requiring hospitalisation over the study period · adults and children with chronic asthma

Macrolides showed no clear difference in exacerbation requiring hospitalisation Weighted mean study duration:… compared with placebo (moderate certainty).

1 finding from 1 review

Macrolides vs placebo

Severe exacerbations (requiring ED visits or systemic steroids, or both) Number of people having ≥ 1 exacerbations requiring an ED visit or systemic steroids, or both. Classification varied across studies. Weighted mean study duration: 35 weeks · adults and children with chronic asthma

Macrolides probably leads to lower severe exacerbations (requiring ED visits or systemic steroids, or… compared with placebo (moderate certainty).

1 finding from 1 review

Macrolides vs placebo

Serious adverse events (including mortality) · adults and children with chronic asthma

Macrolides showed no clear difference in serious adverse events (including mortality) Weighted mean study… compared with placebo (low certainty).

1 finding from 1 review

Macrolides vs placebo

Exacerbations (number of people experiencing ≥ 1 exacerbations) · adults with bronchiectasis

Macrolides probably leads to lower ≥ 1 exacerbation compared with placebo (moderate certainty).

1 finding from 1 review

Macrolides vs placebo

Exacerbation frequency · children with bronchiectasis

Macrolides may leads to lower exacerbation frequency compared with placebo (low certainty).

1 finding from 1 review

Macrolides vs placebo

Hospitalisation (any cause) · children with bronchiectasis

Macrolides showed no clear difference in hospitalisation: all‐cause compared with placebo (low certainty).

1 finding from 1 review

Macrolides vs placebo

Serious adverse events · children with bronchiectasis

Macrolides showed no clear difference in serious adverse events compared with placebo (low certainty).

1 finding from 1 review