evidencegaps
Findings

What do systematic reviews say?

Refine by population, intervention, comparison or outcome
More filters
Evidence found and GRADE certainty

44 questions · 45 findings · 5 reviews

Sort:Best matchNewestHighest certaintyDownload CSV
No studies found 10 · 22.2%GRADE not reported 1 · 2.2%Very low 8 · 17.8%Low 20 · 44.4%Moderate 6 · 13.3%High 0 · 0%

Macrolides vs placebo

Exacerbation frequency · children with bronchiectasis

Macrolides may leads to lower exacerbation frequency compared with placebo (low certainty).

1 finding from 1 review

Macrolides vs placebo

Hospitalisation (any cause) · children with bronchiectasis

Macrolides showed no clear difference in hospitalisation: all‐cause compared with placebo (low certainty).

1 finding from 1 review

Macrolides vs placebo

Serious adverse events · children with bronchiectasis

Macrolides showed no clear difference in serious adverse events compared with placebo (low certainty).

1 finding from 1 review

Macrolides vs placebo

Hospitalisation (any cause) · adults with bronchiectasis

Macrolides showed no clear difference in hospitalisation: all cause compared with placebo (low certainty).

1 finding from 1 review

Macrolides vs placebo

Serious adverse events · adults with bronchiectasis

Macrolides showed no clear difference in serious adverse events compared with placebo (low certainty).

1 finding from 1 review

Macrolides vs placebo

Quality of life: 1a. Average endpoint scores on various scales (MSQoL‐54, high = good) ‐ short term · adults with bronchiectasis
1 finding from 1 review

Macrolides vs no intervention

Exacerbations (number of people experiencing ≥ 1 exacerbations) · adults with bronchiectasis

Macrolides showed no clear difference in ≥ 1 exacerbation compared with no intervention (moderate certainty).

1 finding from 1 review

Regimens containing macrolides (azithromycin) vs regimens containing tetracycline (doxycycline)

Clinical cure according to criteria established by study authors Mild‐moderate PID · women with PID

It is very uncertain whether regimens containing macrolides (azithromycin) changes clinical cure according to criteria established by study authors… compared with regimens containing tetracycline (doxycycline) (very low certainty).

2 findings from 1 review

Regimens containing macrolides (azithromycin) vs regimens containing tetracycline (doxycycline)

Clinical cure according to criteria established by study authors Severe PID · women with PID

Regimens containing macrolides (azithromycin) showed no clear difference in clinical cure according to criteria established by study authors… compared with regimens containing tetracycline (doxycycline) (low certainty).

1 finding from 1 review