What do systematic reviews say?

Lower vs higher oxygen concentrations titrated to target oxygen saturations during resuscitation of preterm infants at birth

Lower showed no clear difference in mortality, near term corrected age or discharge compared with higher oxygen concentrations titrated to target oxygen saturations… (low certainty).

• Lower versus higher oxygen concentrations titrated to target oxygen saturations during resuscitation of preterm… 2018 · Cochrane Headline outcomes only
  RR 1.05 [0.68, 1.63]
  10 studies · 914 participants
  Low

Lower vs higher oxygen concentrations titrated to target oxygen saturations during resuscitation of preterm infants at birth

Lower showed no clear difference in neurodevelopmental disability compared with higher oxygen concentrations titrated to target oxygen saturations… (low certainty).

• Lower versus higher oxygen concentrations titrated to target oxygen saturations during resuscitation of preterm… 2018 · Cochrane Headline outcomes only
  RR 0.82 [0.49, 1.35]
  2 studies · 208 participants
  Low

Lower vs higher oxygen concentrations titrated to target oxygen saturations during resuscitation of preterm infants at birth

Lower showed no clear difference in intubation in the delivery room compared with higher oxygen concentrations titrated to target oxygen saturations… (low certainty).

• Lower versus higher oxygen concentrations titrated to target oxygen saturations during resuscitation of preterm… 2018 · Cochrane Headline outcomes only
  RR 0.98 [0.82, 1.18]
  9 studies · 875 participants
  Low

Lower vs higher oxygen concentrations titrated to target oxygen saturations during resuscitation of preterm infants at birth

Lower showed no clear difference in severe retinopathy of prematurity (≥ stage 3) compared with higher oxygen concentrations titrated to target oxygen saturations… (low certainty).

• Lower versus higher oxygen concentrations titrated to target oxygen saturations during resuscitation of preterm… 2018 · Cochrane Headline outcomes only
  RR 0.57 [0.24, 1.36]
  4 studies · 453 participants
  Low

Lower vs higher oxygen concentrations titrated to target oxygen saturations during resuscitation of preterm infants at birth

Lower showed no clear difference in severe intraventricular haemorrhage (grade 3 or 4) compared with higher oxygen concentrations titrated to target oxygen saturations… (low certainty).

• Lower versus higher oxygen concentrations titrated to target oxygen saturations during resuscitation of preterm… 2018 · Cochrane Headline outcomes only
  RR 0.93 [0.51, 1.71]
  6 studies · 596 participants
  Low

Lower vs higher oxygen concentrations titrated to target oxygen saturations during resuscitation of preterm infants at birth

Lower showed no clear difference in necrotising enterocolitis compared with higher oxygen concentrations titrated to target oxygen saturations… (low certainty).

• Lower versus higher oxygen concentrations titrated to target oxygen saturations during resuscitation of preterm… 2018 · Cochrane Headline outcomes only
  RR 0.98 [0.51, 1.87]
  8 studies · 807 participants
  Low

Lower vs higher oxygen concentrations titrated to target oxygen saturations during resuscitation of preterm infants at birth

It is very uncertain whether lower changes chronic lung disease (36 weeks' corrected age) compared with higher oxygen concentrations titrated to target oxygen saturations… (very low certainty).

• Lower versus higher oxygen concentrations titrated to target oxygen saturations during resuscitation of preterm… 2018 · Cochrane Headline outcomes only
  RR 0.91 [0.72, 1.14]
  9 studies · 862 participants
  Very low

Lower vs higher cumulative dose dexamethasone regimen

Lower showed no clear difference in death or bronchopulmonary dysplasia at 36 weeks PMA compared with higher cumulative dose dexamethasone regimen (low certainty).

• Systemic corticosteroid regimens for prevention of bronchopulmonary dysplasia in preterm infants 2023 · Cochrane Headline outcomes only
  RR 1.03 [0.86, 1.24]
  7 studies · 268 participants
  Low

Lower vs higher cumulative dose dexamethasone regimen

Lower showed no clear difference in death or cerebral palsy at 1 to 3 years compared with higher cumulative dose dexamethasone regimen (low certainty).

• Systemic corticosteroid regimens for prevention of bronchopulmonary dysplasia in preterm infants 2023 · Cochrane Headline outcomes only
  RR 1.74 [0.94, 3.24]
  4 studies · 193 participants
  Low

Lower vs higher cumulative dose dexamethasone regimen

It is very uncertain whether lower changes death or abnormal neurodevelopmental outcome (various definitions)… compared with higher cumulative dose dexamethasone regimen (very low certainty).

• Systemic corticosteroid regimens for prevention of bronchopulmonary dysplasia in preterm infants 2023 · Cochrane Headline outcomes only
  RR 1.86 [0.98, 3.53]
  3 studies · 100 participants
  Very low

Transfer from incubator to cot at lower vs higher body weight

• Transfer of preterm infants from incubator to open cot at lower versus higher body weight 2011 · Cochrane Headline outcomes only
  no estimate extracted
  2 studies · 276 participants
  High

Transfer from incubator to cot at lower vs higher body weight

Transfer from incubator to cot at lower showed no clear difference in proportion of infants having at least one episode of low temperature… compared with higher body weight (high certainty).

• Transfer of preterm infants from incubator to open cot at lower versus higher body weight 2011 · Cochrane Headline outcomes only
  RR 1.43 [0.78, 2.62]
  2 studies · 276 participants
  High

Transfer from incubator to cot at lower vs higher body weight

Transfer from incubator to cot at lower showed no clear difference in proportion of infants having at least one episode of returning to… compared with higher body weight (moderate certainty).

• Transfer of preterm infants from incubator to open cot at lower versus higher body weight 2011 · Cochrane Headline outcomes only
  RR 1.78 [0.77, 4.08]
  3 studies · 336 participants
  Moderate

Transfer from incubator to cot at lower vs higher body weight

• Transfer of preterm infants from incubator to open cot at lower versus higher body weight 2011 · Cochrane Headline outcomes only
  no estimate extracted
  2 studies · 276 participants
  High

Transfer from incubator to cot at lower vs higher body weight

• Transfer of preterm infants from incubator to open cot at lower versus higher body weight 2011 · Cochrane Headline outcomes only
  no estimate extracted
  2 studies · 276 participants
  High

Transfer from incubator to cot at lower vs higher body weight

• Transfer of preterm infants from incubator to open cot at lower versus higher body weight 2011 · Cochrane Headline outcomes only
  no estimate extracted
  2 studies · 276 participants
  High

Transfer from incubator to cot at lower vs higher body weight

Transfer from incubator to cot at lower showed no clear difference in proportion of infants exclusive breastfeeding at discharge compared with higher body weight (high certainty).

• Transfer of preterm infants from incubator to open cot at lower versus higher body weight 2011 · Cochrane Headline outcomes only
  RR 1 [0.81, 1.24]
  2 studies · 276 participants
  High