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Evidence found and GRADE certainty

8 questions · 8 findings · 1 reviews · Headline outcomes only

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No studies found 3 · 37.5%GRADE not reported 0 · 0%Very low 0 · 0%Low 0 · 0%Moderate 0 · 0%High 5 · 62.5%

Low dose isotretinoin 0.3 mg/kg vs doxycycline

Participant‐assessed improvement in rosacea severity · Participants with rosacea

Low dose isotretinoin 0.3 mg/kg leads to higher participant‐assessed improvement in rosacea severity1 Good to… compared with doxycycline 50‐100 mg (high certainty).

1 finding from 1 review

Low dose isotretinoin 0.3 mg/kg vs doxycycline

Proportion of participants with adverse event · Participants with rosacea

Low dose isotretinoin 0.3 mg/kg showed no clear difference in proportion of participants with adverse event compared with doxycycline 50‐100 mg (high certainty).

1 finding from 1 review

Low dose isotretinoin 0.3 mg/kg vs doxycycline

Physician‐assessed improvement in rosacea severity · Participants with rosacea

Low dose isotretinoin 0.3 mg/kg leads to higher physician‐assessed improvement in rosacea severity1 Complete… compared with doxycycline 50‐100 mg (high certainty).

1 finding from 1 review

Low dose isotretinoin 0.3 mg/kg vs doxycycline

Assessment of erythema or telangiectasia Improved or healed · Participants with rosacea

Low dose isotretinoin 0.3 mg/kg showed no clear difference in assessment of erythema or telangiectasia Improved or healed compared with doxycycline 50‐100 mg (high certainty).

1 finding from 1 review