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What do systematic reviews say?

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Evidence found and GRADE certainty

10 questions · 10 findings · 2 reviews · Haematology

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No studies found 1 · 10%GRADE not reported 3 · 30%Very low 0 · 0%Low 3 · 30%Moderate 1 · 10%High 2 · 20%

Chemotherapy plus lower‐dose radiation vs same chemotherapy plus higher‐dose radiation

Secondary malignant neoplasms · Patients with untreated Hodgkin lymphoma (early stages)

Chemotherapy plus lower‐dose radiation showed no clear difference in secondary malignant neoplasms compared with same chemotherapy plus higher‐dose radiation (low certainty).

1 finding from 1 review

Chemotherapy plus lower‐dose radiation vs same chemotherapy plus higher‐dose radiation

Death · Patients with untreated Hodgkin lymphoma (early stages)

Chemotherapy plus lower‐dose radiation showed no clear difference in death compared with same chemotherapy plus higher‐dose radiation (high certainty).

1 finding from 1 review

Chemotherapy plus lower‐dose radiation vs same chemotherapy plus higher‐dose radiation

Progression/relapse · Patients with untreated Hodgkin lymphoma (early stages)

Chemotherapy plus lower‐dose radiation showed no clear difference in progression/relapse compared with same chemotherapy plus higher‐dose radiation (high certainty).

1 finding from 1 review

Prophylactic platelet transfusions with low‐dose schedule vs high‐dose schedule

Number of participants with WHO grade 3 or 4 bleeding up to 30 days from study entry · People with a haematological disorder

Prophylactic platelet transfusions with low‐dose schedule showed no clear difference in number of participants with WHO grade 3 or 4 bleeding up to 30 days… compared with high‐dose schedule (low certainty).

1 finding from 1 review

Prophylactic platelet transfusions with low‐dose schedule vs high‐dose schedule

Mortality from all causes up to 30 days from study entry · People with a haematological disorder

Prophylactic platelet transfusions with low‐dose schedule showed no clear difference in mortality from all causes up to 30 days from study entry compared with high‐dose schedule (low certainty).

1 finding from 1 review

Prophylactic platelet transfusions with low‐dose schedule vs high‐dose schedule

Number of participants with at least 1 clinically significant bleeding event up to 30 days from study entry · People with a haematological disorder

Prophylactic platelet transfusions with low‐dose schedule showed no clear difference in number of participants with at least 1 clinically significant… compared with high‐dose schedule (moderate certainty).

1 finding from 1 review