Findings

What do systematic reviews say?

7 questions · 7 findings · 1 reviews · Cystic Fibrosis and Genetic Disorders

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No studies found 2 · 28.6%GRADE not reported 0 · 0%Very low 2 · 28.6%Low 3 · 42.9%Moderate 0 · 0%High 0 · 0%

Long‐term red cell transfusion vs usual care

SCD ‐ related SAEs ‐ ACS · prevention of SCI in people with SCD and abnormal TCD velocities

Long‐term RBC transfusion may leads to lower SCD ‐ related SAEs ‐ ACS compared with standard care (low certainty).

1 finding from 1 review

Interventions for preventing silent cerebral infarcts in people with sickle cell disease 2020 · Cochrane Headline outcomes only
RR 0.3 [0.11, 0.87]
1 study · 130 participants
Low

Long‐term red cell transfusion vs usual care

SCD‐related SAEs ‐ pain crisis · prevention of SCI in people with SCD and abnormal TCD velocities

It is very uncertain whether long‐term RBC transfusion changes SCD‐related SAEs ‐ pain crisis compared with standard care (very low certainty).

1 finding from 1 review

Interventions for preventing silent cerebral infarcts in people with sickle cell disease 2020 · Cochrane Headline outcomes only
RR 0.9 [0.44, 1.86]
1 study · 130 participants
Very low

Long‐term red cell transfusion vs usual care

Stroke · prevention of SCI in people with SCD and abnormal TCD velocities

Long‐term RBC transfusion may leads to lower clinical stroke compared with standard care (low certainty).

1 finding from 1 review

Interventions for preventing silent cerebral infarcts in people with sickle cell disease 2020 · Cochrane Headline outcomes only
RR 0.1 [0.01, 0.73]
1 study · 130 participants
Low

Long‐term red cell transfusion vs usual care

Cognitive function ‐ not reported · prevention of SCI in people with SCD and abnormal TCD velocities

The review found no eligible studies for this question.

1 finding from 1 review

Interventions for preventing silent cerebral infarcts in people with sickle cell disease 2020 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Long‐term red cell transfusion vs usual care

Quality of life ‐ not reported · prevention of SCI in people with SCD and abnormal TCD velocities

The review found no eligible studies for this question.

1 finding from 1 review

Interventions for preventing silent cerebral infarcts in people with sickle cell disease 2020 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Long‐term red cell transfusion vs usual care

Proportion of participants developing new or progressive SCI lesions · prevention of SCI in people with SCD and abnormal TCD velocities

Long‐term RBC transfusion may leads to lower proportion of participants developing new or progressive SCI lesions compared with standard care (low certainty).

1 finding from 1 review

Interventions for preventing silent cerebral infarcts in people with sickle cell disease 2020 · Cochrane Headline outcomes only
RR 0.11 [0.02, 0.86]
1 study · 124 participants
Low

Long‐term red cell transfusion vs usual care

All‐cause mortality · prevention of SCI in people with SCD and abnormal TCD velocities

1 finding from 1 review

Interventions for preventing silent cerebral infarcts in people with sickle cell disease 2020 · Cochrane Headline outcomes only
no estimate extracted
1 study · 130 participants
Very low