What do systematic reviews say?

Local excision vs radical resection

The review found no eligible studies for this question.

• Local versus radical surgery for early rectal cancer with or without neoadjuvant or adjuvant therapy 2023 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

Local excision vs radical resection

Local excision showed no clear difference in disease‐free survival (D‐FS)Â compared with radical resection (low certainty).

• Local versus radical surgery for early rectal cancer with or without neoadjuvant or adjuvant therapy 2023 · Cochrane Headline outcomes only
  HR 1.96 [0.91, 4.24]
  3 studies · 212 participants
  Low

Local excision vs radical resection

• Local versus radical surgery for early rectal cancer with or without neoadjuvant or adjuvant therapy 2023 · Cochrane Headline outcomes only
  no estimate extracted
  3 studies · 165 participants
  Low

Local excision vs radical resection

It is very uncertain whether local excision changes cancer‐related survival (C‐RS)Â compared with radical resection (very low certainty).

• Local versus radical surgery for early rectal cancer with or without neoadjuvant or adjuvant therapy 2023 · Cochrane Headline outcomes only
  HR 1.42 [0.6, 3.33]
  3 studies · 207 participants
  Very low

Local excision vs radical resection

• Local versus radical surgery for early rectal cancer with or without neoadjuvant or adjuvant therapy 2023 · Cochrane Headline outcomes only
  no estimate extracted
  4 studies · 265 participants
  Low

Local excision vs radical resection

Local excision showed no clear difference in major postoperative complications compared with radical resection (low certainty).

• Local versus radical surgery for early rectal cancer with or without neoadjuvant or adjuvant therapy 2023 · Cochrane Headline outcomes only
  RR 0.53 [0.22, 1.28]
  4 studies · 266 participants
  Low

Local excision vs radical resection

Local excision probably leads to lower minor postoperative complications compared with radical resection (moderate certainty).

• Local versus radical surgery for early rectal cancer with or without neoadjuvant or adjuvant therapy 2023 · Cochrane Headline outcomes only
  RR 0.48 [0.27, 0.85]
  4 studies · 266 participants
  Moderate

Local excision vs radical resection

• Local versus radical surgery for early rectal cancer with or without neoadjuvant or adjuvant therapy 2023 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 55 participants
  Low