Findings

What do systematic reviews say?

7 questions · 7 findings · 1 reviews · Acute Respiratory Infections

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No studies found 0 · 0%GRADE not reported 0 · 0%Very low 0 · 0%Low 0 · 0%Moderate 7 · 100%High 0 · 0%

Live zoster vaccine vs placebo

Participants with adverse events: 1 or more serious adverse events regardless of type of storage of the vaccine Clinical or laboratory criteria · healthy older adults aged ≥ 60 years

Live zoster vaccine showed no clear difference in participants with adverse events: 1 or more serious adverse events… compared with placebo (moderate certainty).

1 finding from 1 review

Vaccines for preventing herpes zoster in older adults 2023 · Cochrane Headline outcomes only
RR 1.08 [0.95, 1.21]
6 studies · 51029 participants
Moderate

Live zoster vaccine vs placebo

Cumulative incidence of herpes zoster, 3.1 years · healthy older adults aged ≥ 60 years

Live zoster vaccine probably leads to lower cumulative incidence of herpes zoster, 3.1 years compared with placebo (moderate certainty).

1 finding from 1 review

Vaccines for preventing herpes zoster in older adults 2023 · Cochrane Headline outcomes only
RR 0.49 [0.43, 0.56]
1 study · 38546 participants
Moderate

Live zoster vaccine vs placebo

Participants with adverse events Clinical or laboratory criteria · healthy older adults aged ≥ 60 years

Live zoster vaccine probably leads to higher participants with adverse eventsClinical or laboratory criteria compared with placebo (moderate certainty).

1 finding from 1 review

Vaccines for preventing herpes zoster in older adults 2023 · Cochrane Headline outcomes only
RR 1.71 [1.38, 2.11]
5 studies · 7119 participants
Moderate

Live zoster vaccine vs placebo

DeathClinical criteria · healthy older adults aged ≥ 60 years

Live zoster vaccine showed no clear difference in deathClinical criteria compared with placebo (moderate certainty).

1 finding from 1 review

Vaccines for preventing herpes zoster in older adults 2023 · Cochrane Headline outcomes only
RR 1.01 [0.92, 1.11]
5 studies · 50820 participants
Moderate

Live zoster vaccine vs placebo

Systemic adverse events at · healthy older adults aged ≥ 60 years

Live zoster vaccine showed no clear difference in participants with adverse events ‐ systemic adverse eventsClinical… compared with placebo (moderate certainty).

1 finding from 1 review

Vaccines for preventing herpes zoster in older adults 2023 · Cochrane Headline outcomes only
RR 1.24 [0.82, 1.87]
5 studies · 7119 participants
Moderate

Live zoster vaccine vs placebo

Participants with adverse events ‐ injection site adverse events Clinical criteria · healthy older adults aged ≥ 60 years

Live zoster vaccine probably leads to higher participants with adverse events ‐ injection site adverse… compared with placebo (moderate certainty).

1 finding from 1 review

Vaccines for preventing herpes zoster in older adults 2023 · Cochrane Headline outcomes only
RR 3.73 [1.93, 7.21]
4 studies · 7040 participants
Moderate

Live zoster vaccine vs placebo

Dropouts Clinical or laboratory criteria · healthy older adults aged ≥ 60 years

Live zoster vaccine showed no clear difference in dropoutsClinical or laboratory criteria compared with placebo (moderate certainty).

1 finding from 1 review

Vaccines for preventing herpes zoster in older adults 2023 · Cochrane Headline outcomes only
RR 0.99 [0.9, 1.08]
3 studies · 38916 participants
Moderate