Findings

What do systematic reviews say?

4 questions · 4 findings · 1 reviews

No studies found 1 · 25%GRADE not reported 0 · 0%Very low 0 · 0%Low 0 · 0%Moderate 0 · 0%High 3 · 75%

Efficacy: response (categorical) YMRS change ≥ 50% from baseline to end of study · acute mania

Lithium leads to higher efficacy: response (categorical) YMRS change ≥ 50% from baseline to… compared with topiramate (high certainty).

1 finding from 1 review

Lithium for acute mania 2019 · Cochrane Headline outcomes only
OR 2.28 [1.63, 3.2]
1 study · 660 participants
High

Efficacy: response (continuous) YMRS change by ≥ 50% at end of study · acute mania

The review found no eligible studies for this question.

1 finding from 1 review

Lithium for acute mania 2019 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Remission · acute mania

Lithium leads to higher efficacy: remission (categorical) YMRS ≤ 12 at end of study compared with topiramate (high certainty).

1 finding from 1 review

Lithium for acute mania 2019 · Cochrane Headline outcomes only
OR 2.24 [1.58, 3.15]
1 study · 660 participants
High

Acceptability: total withdrawals · acute mania

Lithium showed no clear difference in acceptability: total withdrawals compared with topiramate (high certainty).

1 finding from 1 review

Lithium for acute mania 2019 · Cochrane Headline outcomes only
OR 1.28 [0.66, 2.48]
2 studies · 1352 participants
High