Findings

What do systematic reviews say?

6 questions · 6 findings · 1 reviews

No studies found 2 · 33.3%GRADE not reported 0 · 0%Very low 1 · 16.7%Low 0 · 0%Moderate 3 · 50%High 0 · 0%

Efficacy: response (categorical) YMRS/SADS‐C decrease ≥ 50% by end of study · acute mania

The review found no eligible studies for this question.

1 finding from 1 review

Lithium for acute mania 2019 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Efficacy: response (continuous) change in BPRS (total) from baseline to end of study ‐all data · acute mania

1 finding from 1 review

Lithium for acute mania 2019 · Cochrane Headline outcomes only
no estimate extracted
3 studies · 301 participants
Moderate

Efficacy: remission (categorical) YMRS ≤ 12 and no increase in MADRS at end of study · acute mania

The review found no eligible studies for this question.

1 finding from 1 review

Lithium for acute mania 2019 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Acceptability: total withdrawals · acute mania

It is very uncertain whether lithium changes acceptability: total withdrawals compared with lamotrigine (very low certainty).

1 finding from 1 review

Lithium for acute mania 2019 · Cochrane Headline outcomes only
OR 0.8 [0.5, 1.29]
3 studies · 303 participants
Very low

Adverse event: tremor · acute mania

Lithium showed no clear difference in adverse event: tremor compared with lamotrigine (moderate certainty).

1 finding from 1 review

Lithium for acute mania 2019 · Cochrane Headline outcomes only
OR 1.28 [0.48, 3.41]
2 studies · 272 participants
Moderate

Somnolence · acute mania

Lithium showed no clear difference in adverse event: somnolence compared with lamotrigine (moderate certainty).

1 finding from 1 review

Lithium for acute mania 2019 · Cochrane Headline outcomes only
OR 1.14 [0.34, 3.85]
2 studies · 272 participants
Moderate