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What do systematic reviews say?

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Evidence found and GRADE certainty

4 questions · 4 findings · 2 reviews

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No studies found 0 · 0%GRADE not reported 0 · 0%Very low 0 · 0%Low 2 · 50%Moderate 1 · 25%High 1 · 25%

Letrozole with or without adjuncts vs SERMs with or without adjuncts followed by timed intercourse

Clinical pregnancy rate · infertile women with polycystic ovary syndrome

Letrozole with or without adjuncts leads to higher clinical pregnancy rate compared with SERMs with or without adjuncts followed by timed intercourse (high certainty).

1 finding from 1 review

Clomiphene citrate or letrozole with or without gonadotropins (with or without midcycle antagonist) vs gonadotropins (with GnRH agonists or midcycle antagonist)

Clinical pregnancy rate · for controlled ovarian stimulation

Clomiphene citrate or letrozole with or without gonadotropins (with… showed no clear difference in clinical pregnancy rate per woman compared with gonadotropins (with GnRH agonists or midcycle antagonist) (moderate certainty).

1 finding from 1 review

Clomiphene citrate or letrozole with or without gonadotropins (with or without midcycle antagonist) vs gonadotropins (with GnRH agonists or midcycle antagonist)

Clinical pregnancy rate · Women undergoing controlled ovarian stimulation in IVF and ICSI cycles (poor responders)

Clomiphene citrate or letrozole with or without gonadotropins (with… showed no clear difference in clinical pregnancy rate per woman compared with gonadotropins (with GnRH agonist or midcycle antagonist) (low certainty).

1 finding from 1 review