Findings

What do systematic reviews say?

3 questions · 3 findings · 1 reviews · Headline outcomes only

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No studies found 1 · 33.3%GRADE not reported 0 · 0%Very low 0 · 0%Low 2 · 66.7%Moderate 0 · 0%High 0 · 0%

Late paracetamol vs placebo or no intervention

Failure of PDA closure after first course of treatment (assessed by post‐treatment ECHO) · preterm or low birth weight infants with PDA

Late paracetamol showed no clear difference in failure of PDA closure after first course of treatment (assessed by… compared with placebo/no intervention (low certainty).

1 finding from 1 review

Paracetamol (acetaminophen) for patent ductus arteriosus in preterm or low birth weight infants 2022 · Cochrane Headline outcomes only
RR 0.85 [0.72, 1.01]
1 study · 55 participants
Low

Late paracetamol vs placebo or no intervention

All‐cause mortality during hospital stay · preterm or low birth weight infants with PDA

The review found no eligible studies for this question.

1 finding from 1 review

Paracetamol (acetaminophen) for patent ductus arteriosus in preterm or low birth weight infants 2022 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Late paracetamol vs placebo or no intervention

Necrotizing enterocolitis during initial hospital stay (by radiological diagnosis) · preterm or low birth weight infants with PDA

Late paracetamol showed no clear difference in necrotizing enterocolitis during initial hospital stay (by… compared with placebo/no intervention (low certainty).

1 finding from 1 review

Paracetamol (acetaminophen) for patent ductus arteriosus in preterm or low birth weight infants 2022 · Cochrane Headline outcomes only
RR 1.04 [0.07, 15.76]
1 study · 55 participants
Low