Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

48 questions · 53 findings · 8 reviews · Oral Health

No studies found 15 · 28.3%GRADE not reported 26 · 49.1%Very low 11 · 20.8%Low 1 · 1.9%Moderate 0 · 0%High 0 · 0%

Low‐level laser therapy vs Placebo (sham) laser therapy

Mucositis severity (mild to moderate) · People with cancer receiving chemotherapy or radiotherapy (or both) who have oral mucositis

Low level laser therapy led to higher mucositis severity (mild to moderate) compared with sham (placebo) laser treatment; GRADE not reported.

1 finding from 1 review

Low‐level laser therapy vs Low-level laser therapy (LLLT) + calcium hydroxide

Radiological failure · Children with extensive decay involving the dental pulp in primary teeth

Low-level laser therapy (LLLT) showed no clear difference in radiological failure compared with low-level laser therapy (LLLT) + calcium hydroxide; GRADE not reported.

1 finding from 1 review

Low‐level laser therapy vs Control (no laser device used)

Maximum pain (verbal rating scale, VRS) · People requiring retreatment of periapical lesions (failed root canal therapy)

It is very uncertain whether low energy level laser therapy (LLLT) changes maximum pain (verbal rating scale, VRS) compared with control (no laser device used) (very low certainty).

1 finding from 1 review

Low‐level laser therapy vs Placebo (sham) laser therapy

Patient-reported altered sensation (spontaneous or evoked: anaesthesia/paraesthesia/dysaesthesia/hyperalgesia/allodynia) · Patients of any age in any setting requiring intervention for iatrogenic injury to the inferior alveolar or lingual nerve

It is very uncertain whether low-level laser therapy (photon-plus GaAlAs diode laser; 70 mW… changes patient-reported altered sensation (spontaneous or evoked:… compared with placebo (sham) laser therapy (very low certainty).

2 findings from 1 review

Low‐level laser therapy vs Placebo (sham) laser therapy

Somatosensory evoked potentials · Patients of any age in any setting requiring intervention for iatrogenic injury to the inferior alveolar or lingual nerve

The review found no eligible studies for this question.

1 finding from 1 review

Low‐level laser therapy vs Placebo (sham) laser therapy

Mechanosensory perception (load in grams to elicit sensation; Semmes Weinstein monofilaments) · Patients of any age in any setting requiring intervention for iatrogenic injury to the inferior alveolar or lingual nerve

Low-level laser therapy (photon-plus GaAlAs diode laser; 70 mW… led to higher mechanosensory perception (load in grams to elicit sensation; Semmes… compared with placebo (sham) laser therapy; GRADE not reported.

1 finding from 1 review

Low‐level laser therapy vs Placebo (sham) laser therapy

Thermosensory (thermal) perception · Patients of any age in any setting requiring intervention for iatrogenic injury to the inferior alveolar or lingual nerve

Low-level laser therapy (photon-plus GaAlAs diode laser; 70 mW… showed no clear difference in thermosensory (thermal) perception compared with placebo (sham) laser therapy; GRADE not reported.

1 finding from 1 review

Low‐level laser therapy vs Placebo (sham) laser therapy

Patient satisfaction · Patients of any age in any setting requiring intervention for iatrogenic injury to the inferior alveolar or lingual nerve

The review found no eligible studies for this question.

1 finding from 1 review

Low‐level laser therapy vs Conventional orthodontic appliance treatment

Rate of orthodontic tooth movement during space closure stage (maxillary arch), mm/month · Adolescents and adults with malocclusion undergoing fixed orthodontic appliance treatment

It is very uncertain whether low level laser therapy (LLLT) changes rate of orthodontic tooth movement during space closure stage… compared with conventional orthodontic appliance treatment (very low certainty).

1 finding from 1 review

Low‐level laser therapy vs Conventional orthodontic appliance treatment

Side effects or other adverse events · Adolescents and adults with malocclusion undergoing fixed orthodontic appliance treatment
1 finding from 1 review

Low‐level laser therapy vs Conventional orthodontic appliance treatment

Periodontal health during molar intrusion · Adolescents and adults with malocclusion undergoing fixed orthodontic appliance treatment
1 finding from 1 review

Low‐level laser therapy vs Conventional orthodontic appliance treatment

Total number of orthodontic appliance adjustment appointments during alignment stage · Adolescents and adults with malocclusion undergoing fixed orthodontic appliance treatment

It is very uncertain whether low level laser therapy (LLLT) changes total number of orthodontic appliance adjustment appointments during… compared with conventional orthodontic appliance treatment (very low certainty).

1 finding from 1 review