Lamotrigine plus ASMs vs placebo plus ASMs
Seizure freedom · Lennox‐Gastaut syndrome, any age
The review found no eligible studies for this question.
1 finding from 1 review
- no estimate extractedStudies not reportedNo studies found
Findings
What do systematic reviews say?
4 questions · 4 findings · 1 reviews
No studies found 2 · 50%GRADE not reported 0 · 0%Very low 0 · 0%Low 1 · 25%Moderate 0 · 0%High 1 · 25%
Lamotrigine plus ASMs vs placebo plus ASMs
Number of participants with ≥ 75% reduction in all seizures · Lennox‐Gastaut syndrome, any age
The review found no eligible studies for this question.
1 finding from 1 review
- no estimate extractedStudies not reportedNo studies found
Lamotrigine plus ASMs vs placebo plus ASMs
50% or greater reduction in seizure frequency · Lennox‐Gastaut syndrome, any age
Lamotrigine plus ASMs leads to higher number of participants with ≥ 50% median reduction in all seizures compared with placebo plus ASMs (high certainty).
1 finding from 1 review
- RR 2.12 [1.19, 3.76]1 study · 167 participantsHigh
Lamotrigine plus ASMs vs placebo plus ASMs
Number of participants with adverse events leading to study discontinuation · Lennox‐Gastaut syndrome, any age
Lamotrigine plus ASMs showed no clear difference in number of participants with adverse events leading to study… compared with placebo plus ASMs (low certainty).
1 finding from 1 review
- RR 0.49 [0.13, 1.82]1 study · 169 participantsLow