Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

66 questions · 66 findings · 9 reviews

No studies found 6 · 9.1%GRADE not reported 10 · 15.2%Very low 16 · 24.2%Low 7 · 10.6%Moderate 21 · 31.8%High 6 · 9.1%

Lamotrigine vs carbamazepine

Time to treatment failure (any reason related to treatment) Subgroup: focal onset seizures Range of · adults and children with focal onset or generalised onset seizures (generalised tonic‐clonic with or without other generalised seizure…

Summary of findings: lamotrigine probably leads to lower time to treatment failure (any reason related to treatment)… compared with carbamazepine (moderate certainty).

1 finding from 1 review

Lamotrigine vs carbamazepine

Time to treatment failure (any reason related to treatment) Subgroup: generalised onset seizures Range of · adults and children with focal onset or generalised onset seizures (generalised tonic‐clonic with or without other generalised seizure…

Summary of findings: lamotrigine may leads to lower time to treatment failure (any reason related to treatment)… compared with carbamazepine (low certainty).

1 finding from 1 review

Lamotrigine vs carbamazepine

Time to first seizure ‐ all participants Range of · adults and children with focal onset or generalised onset seizures (generalised tonic‐clonic with or without other generalised seizure…

Summary of findings: lamotrigine leads to higher time to first seizure All participants Range of compared with carbamazepine (high certainty).

1 finding from 1 review

Lamotrigine vs carbamazepine

Time to first seizure (post‐randomisation) Subgroup: focal onset seizures Range of · adults and children with focal onset or generalised onset seizures (generalised tonic‐clonic with or without other generalised seizure…

Summary of findings: lamotrigine leads to higher time to first seizure Subgroup: focal onset seizures Range of compared with carbamazepine (high certainty).

1 finding from 1 review

Lamotrigine vs carbamazepine

Time to first seizure ‐ generalised epilepsy Range of · adults and children with focal onset or generalised onset seizures (generalised tonic‐clonic with or without other generalised seizure…

Summary of findings: lamotrigine showed no clear difference in time to first seizure Subgroup: generalised onset seizures Range of compared with carbamazepine (low certainty).

1 finding from 1 review

Lamotrigine vs carbamazepine

Time to 12‐month remission ‐ all participants Range of · adults and children with focal onset or generalised onset seizures (generalised tonic‐clonic with or without other generalised seizure…

Summary of findings: lamotrigine showed no clear difference in time to 12‐month remission All participants Range of compared with carbamazepine (high certainty).

1 finding from 1 review