Findings

What do systematic reviews say?

4 questions · 4 findings · 1 reviews

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No studies found 0 · 0%GRADE not reported 0 · 0%Very low 1 · 25%Low 1 · 25%Moderate 2 · 50%High 0 · 0%

Lamotrigine vs placebo

Recurrence of manic episode at one year · bipolar disorder

Lamotrigine showed no clear difference in recurrence of manic episode at one year compared with placebo (moderate certainty).

1 finding from 1 review

Lamotrigine in the maintenance treatment of bipolar disorder 2021 · Cochrane Headline outcomes only
RR 0.91 [0.66, 1.26]
3 studies · 574 participants
Moderate

Lamotrigine vs lithium

Recurrence of manic episode at one year · bipolar disorder

Lamotrigine probably leads to higher recurrence of manic episode at one year compared with lithium (moderate certainty).

1 finding from 1 review

Lamotrigine in the maintenance treatment of bipolar disorder 2021 · Cochrane Headline outcomes only
RR 2.13 [1.32, 3.44]
3 studies · 602 participants
Moderate

Lamotrigine vs lithium

Recurrence of any episodes at one year (Young Mania Rating Scale (YMRS) total score ≥15 for manic episode) · bipolar disorder

It is very uncertain whether lamotrigine changes recurrence of any episodes at one year (Young Mania Rating Scale… compared with lithium (very low certainty).

1 finding from 1 review

Lamotrigine in the maintenance treatment of bipolar disorder 2021 · Cochrane Headline outcomes only
RR 3.57 [0.15, 85.39]
2 studies · 376 participants
Very low

Lamotrigine vs placebo

Recurrence of any episodes at one year (Young Mania Rating Scale (YMRS) total score ≥15 for manic episode) · bipolar disorder

Lamotrigine may leads to lower recurrence of any episodes at one year (Young Mania Rating Scale… compared with placebo (low certainty).

1 finding from 1 review

Lamotrigine in the maintenance treatment of bipolar disorder 2021 · Cochrane Headline outcomes only
RR 0.67 [0.51, 0.87]
3 studies · 663 participants
Low