Findings

What do systematic reviews say?

4 questions · 4 findings · 1 reviews

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No studies found 0 · 0%GRADE not reported 0 · 0%Very low 0 · 0%Low 2 · 50%Moderate 2 · 50%High 0 · 0%

Lamotrigine vs placebo

Recurrence of depressive episode at one year · bipolar disorder

Lamotrigine showed no clear difference in recurrence of depressive episode at one year compared with placebo (moderate certainty).

1 finding from 1 review

Lamotrigine in the maintenance treatment of bipolar disorder 2021 · Cochrane Headline outcomes only
RR 0.75 [0.53, 1.05]
3 studies · 574 participants
Moderate

Lamotrigine vs lithium

Recurrence of depressive episode at one year · bipolar disorder

Lamotrigine showed no clear difference in recurrence of depressive episode at one year compared with lithium (moderate certainty).

1 finding from 1 review

Lamotrigine in the maintenance treatment of bipolar disorder 2021 · Cochrane Headline outcomes only
RR 0.83 [0.63, 1.09]
3 studies · 602 participants
Moderate

Recurrence of any episodes at one year (Montgomery‐Asberg Depression Rating Scale (MADRS) total score ≥15 for depressive episode; Hamilton Depression Rating Scale (HDRS) total score ≥14 for depressive episode) · bipolar disorder

Lamotrigine showed no clear difference in recurrence of any episodes at one year (Montgomery‐Asberg Depression… compared with lithium (low certainty).

1 finding from 1 review

Lamotrigine in the maintenance treatment of bipolar disorder 2021 · Cochrane Headline outcomes only
RR 1.4 [0.7, 2.79]
2 studies · 376 participants
Low

Lamotrigine vs placebo

Lamotrigine showed no clear difference in recurrence of any episodes at one year (Montgomery‐Asberg Depression… compared with placebo (low certainty).

1 finding from 1 review

Lamotrigine in the maintenance treatment of bipolar disorder 2021 · Cochrane Headline outcomes only
RR 0.85 [0.7, 1.02]
7 studies · 1606 participants
Low