All‐cause mortality · prevention of sepsis and necrotizing enterocolitis in preterm infants
It is very uncertain whether lactoferrin supplementation with enteral feeds in combination with… changes all‐cause mortality compared with placebo (very low certainty).
1 finding from 1 review
Bacterial sepsis · prevention of sepsis and necrotizing enterocolitis in preterm infants
Lactoferrin supplementation with enteral feeds in combination with… may leads to lower bacterial sepsis compared with placebo (low certainty).
1 finding from 1 review
Fungal Infection · prevention of sepsis and necrotizing enterocolitis in preterm infants
Lactoferrin supplementation with enteral feeds in combination with… may leads to lower fungal Infection compared with placebo (low certainty).
1 finding from 1 review
Chronic lung disease · prevention of sepsis and necrotizing enterocolitis in preterm infants
It is very uncertain whether lactoferrin supplementation with enteral feeds in combination with… changes chronic lung disease compared with placebo (very low certainty).
1 finding from 1 review
Length of stay among survivors · prevention of sepsis and necrotizing enterocolitis in preterm infants
1 finding from 1 review
Any late‐onset sepsis ‐ All infants [Data on only confirmed sepsis available] · prevention of sepsis and necrotizing enterocolitis in preterm infants
Lactoferrin supplementation with enteral feeds in combination with… may leads to lower any late‐onset sepsis ‐ All infants [Data on only confirmed sepsis… compared with placebo (low certainty).
1 finding from 1 review
NEC ≥ stage II · prevention of sepsis and necrotizing enterocolitis in preterm infants
It is very uncertain whether lactoferrin supplementation with enteral feeds in combination with… changes NEC ≥ stage II compared with placebo (very low certainty).
1 finding from 1 review
All‐cause Mortality№ of participants: 5510(11 RCTs) · prevention of sepsis and necrotizing enterocolitis in preterm infants
It is very uncertain whether lactoferrin supplementation changes all‐cause Mortality№ of participants: 5510(11 RCTs) compared with control (very low certainty).
1 finding from 1 review
RR 0.97 [0.79, 1.2]
Studies not reported
Very low
necrotizing enterocolitis№ of participants: 4874(7 RCTs) · prevention of sepsis and necrotizing enterocolitis in preterm infants
Lactoferrin supplementation showed no clear difference in necrotizing enterocolitis№ of participants: 4874(7 RCTs) compared with control (low certainty).
1 finding from 1 review
RR 0.9 [0.69, 1.17]
Studies not reported
Low
Any late‐onset sepsis ‐ all infants · prevention of sepsis and necrotizing enterocolitis in preterm infants
Lactoferrin supplementation may leads to lower late onset sepsis№ of participants: 5425(12 RCTs) [Data includes… compared with control (low certainty).
1 finding from 1 review
RR 0.8 [0.72, 0.89]
Studies not reported
Low
Bacterial sepsis · prevention of sepsis and necrotizing enterocolitis in preterm infants
Lactoferrin supplementation showed no clear difference in bacterial sepsis№ of participants: 3565(8 RCTs) compared with control (low certainty).
1 finding from 1 review
RR 0.86 [0.74, 1]
Studies not reported
Low
Fungal Infection · prevention of sepsis and necrotizing enterocolitis in preterm infants
Lactoferrin supplementation may leads to lower fungal infection№ of participants: 3266(6 RCTs) compared with control (low certainty).
1 finding from 1 review
RR 0.23 [0.1, 0.54]
Studies not reported
Low
Chronic lung disease · prevention of sepsis and necrotizing enterocolitis in preterm infants
Lactoferrin supplementation showed no clear difference in chronic lung disease№ of participants: 2984(5 RCTs) compared with control (low certainty).
1 finding from 1 review
RR 1 [0.89, 1.12]
Studies not reported
Low
Length of hospital stay · prevention of sepsis and necrotizing enterocolitis in preterm infants
1 finding from 1 review
no estimate extracted
Studies not reported
Very low