What do systematic reviews say?

Participants with a serious adverse event following a single dose · adults with moderate or severe acute postoperative pain

At least 50% of maximum pain relief over 4 to 6 hours · adults with moderate or severe acute postoperative pain

Median (mean) time to use of rescue medication · adults with moderate or severe acute postoperative pain

Number of women requiring rescue medication · adults with moderate or severe acute postoperative pain

Participants with ≥ 1 adverse event following a single dose · adults with moderate or severe acute postoperative pain

Participant‐reported pain relief of 50% or greater · adults with moderate or severe acute postoperative pain

Median (mean) time to use of rescue medication · adults with moderate or severe acute postoperative pain

Number of women requiring rescue medication · adults with moderate or severe acute postoperative pain

Participants with ≥ 1 adverse event following a single dose · adults with moderate or severe acute postoperative pain

Participants with a serious adverse event following a single dose · adults with moderate or severe acute postoperative pain

Pain‐free at 2 hours · adults with episodic tension‐type headache

Pain‐free at different time points (1, 4, 24 hours) · adults with episodic tension‐type headache

Pain‐free or mild pain at 2 hours · adults with episodic tension‐type headache

Use of rescue medication · adults with episodic tension‐type headache

Any adverse event · adults with episodic tension‐type headache

Specific adverse events · adults with episodic tension‐type headache

Serious adverse events · adults with episodic tension‐type headache

At least 50% of maximum pain relief over 4 to 6 hours · adults with moderate or severe acute postoperative pain

Median (mean) time to use of rescue medication · adults with moderate or severe acute postoperative pain

Number of women requiring rescue medication · adults with moderate or severe acute postoperative pain