Findings

What do systematic reviews say?

3 questions · 3 findings · 1 reviews · Kidney and Transplant

No studies found 0 · 0%GRADE not reported 0 · 0%Very low 0 · 0%Low 1 · 33.3%Moderate 2 · 66.7%High 0 · 0%

Tuberculosis · kidney transplant recipients

Isoniazid probably leads to lower tuberculosis compared with no treatment (moderate certainty).

1 finding from 1 review

Antibiotic prophylaxis for preventing post solid organ transplant tuberculosis 2014 · Cochrane Headline outcomes only
RR 0.35 [0.14, 0.89]
3 studies · 558 participants
Moderate

INH hepatotoxicity Jaundice, elevated bilirubin, elevated liver enzymes · kidney transplant recipients

Isoniazid probably leads to higher INH hepatotoxicity Jaundice, elevated bilirubin, elevated liver… compared with no treatment (moderate certainty).

1 finding from 1 review

Antibiotic prophylaxis for preventing post solid organ transplant tuberculosis 2014 · Cochrane Headline outcomes only
RR 1.59 [1.06, 2.4]
3 studies · 558 participants
Moderate

All‐cause mortality · kidney transplant recipients

Isoniazid showed no clear difference in all‐cause mortality compared with no treatment (low certainty).

1 finding from 1 review

Antibiotic prophylaxis for preventing post solid organ transplant tuberculosis 2014 · Cochrane Headline outcomes only
RR 1.39 [0.7, 2.78]
3 studies · 558 participants
Low