Findings

What do systematic reviews say?

3 questions · 3 findings · 1 reviews

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No studies found 0 · 0%GRADE not reported 0 · 0%Very low 0 · 0%Low 0 · 0%Moderate 0 · 0%High 3 · 100%

Intravenous thrombolytic treatment vs standard‐of‐care therapy

Functional outcomes · people with stroke upon awakening

Intravenous thrombolytic treatment leads to higher independent functional outcome at end of compared with standard medical care (high certainty).

1 finding from 1 review

Intravenous thrombolytic treatment and endovascular thrombectomy for ischaemic wake‐up stroke 2021 · Cochrane Headline outcomes only
RR 1.13 [1.01, 1.26]
5 studies · 763 participants
High

Intravenous thrombolytic treatment vs standard‐of‐care therapy

Symptomatic intracranial haemorrhage at · people with stroke upon awakening

Intravenous thrombolytic treatment showed no clear difference in symptomatic intracranial haemorrhage at compared with standard medical care (high certainty).

1 finding from 1 review

Intravenous thrombolytic treatment and endovascular thrombectomy for ischaemic wake‐up stroke 2021 · Cochrane Headline outcomes only
RR 3.47 [0.98, 12.26]
4 studies · 754 participants
High

Intravenous thrombolytic treatment vs standard‐of‐care therapy

Death at · people with stroke upon awakening

Intravenous thrombolytic treatment showed no clear difference in death at compared with standard medical care (high certainty).

1 finding from 1 review

Intravenous thrombolytic treatment and endovascular thrombectomy for ischaemic wake‐up stroke 2021 · Cochrane Headline outcomes only
RR 0.68 [0.43, 1.07]
5 studies · 763 participants
High