Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

450 questions · 474 findings · 58 reviews

No studies found 96 · 20.3%GRADE not reported 49 · 10.3%Very low 102 · 21.5%Low 110 · 23.2%Moderate 77 · 16.2%High 40 · 8.4%

IVIg vs no IVIG

Disease‐specific mortality ‐ SJS and TEN (time to · Stevens‐Johnson syndrome (SJS), toxic epidermal necrolysis (TEN), and SJS/TEN overlap syndrome

It is very uncertain whether intravenous immunoglobulin (IVIG) changes SJS/TEN‐specific mortality (time to compared with no IVIG (very low certainty).

1 finding from 1 review

Intravenous fluid supplementation vs no fluid supplementation

Proportion of infants who required exchange transfusion · newborn infants with unconjugated hyperbilirubinaemia undergoing phototherapy

Intravenous fluid supplementation may leads to lower proportion of infants who required exchange transfusion compared with no fluid supplementation (low certainty).

1 finding from 1 review