Findings

What do systematic reviews say?

7 questions · 7 findings · 1 reviews · Pregnancy and Childbirth

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No studies found 0 · 0%GRADE not reported 0 · 0%Very low 0 · 0%Low 4 · 57.1%Moderate 3 · 42.9%High 0 · 0%

Intravenous/intramuscular ergot alkaloids vs no uterotonic agents

Severe PPH (≥ 1000 mL) · women in the third stage of labour

Intravenous/intramuscular ergot alkaloids may leads to lower estimated or measured blood loss of at least 1000 mL visual estimation compared with no uterotonic agents (low certainty).

1 finding from 1 review

Prophylactic use of ergot alkaloids in the third stage of labour 2018 · Cochrane Headline outcomes only
RR 0.09 [0.01, 0.72]
1 study · 1429 participants
Low

Intravenous/intramuscular ergot alkaloids vs no uterotonic agents

Haemoglobin (g/dL) · women in the third stage of labour

1 finding from 1 review

Prophylactic use of ergot alkaloids in the third stage of labour 2018 · Cochrane Headline outcomes only
no estimate extracted
1 study · 1429 participants
Moderate

Intravenous/intramuscular ergot alkaloids vs no uterotonic agents

Use of therapeutic uterotonics · women in the third stage of labour

Intravenous/intramuscular ergot alkaloids may leads to lower use of therapeutic uterotonics compared with no uterotonic agents (low certainty).

1 finding from 1 review

Prophylactic use of ergot alkaloids in the third stage of labour 2018 · Cochrane Headline outcomes only
RR 0.25 [0.1, 0.66]
2 studies · 2409 participants
Low

Intravenous/intramuscular ergot alkaloids vs no uterotonic agents

Elevation of blood pressure · women in the third stage of labour

Intravenous/intramuscular ergot alkaloids may leads to higher elevation of blood pressure compared with no uterotonic agents (low certainty).

1 finding from 1 review

Prophylactic use of ergot alkaloids in the third stage of labour 2018 · Cochrane Headline outcomes only
RR 2.6 [1.03, 6.57]
3 studies · 2559 participants
Low

Intravenous/intramuscular ergot alkaloids vs no uterotonic agents

Pain after birth requiring analgesia (not prespecified) · women in the third stage of labour

Intravenous/intramuscular ergot alkaloids probably leads to higher pain after birth requiring analgesia (not prespecified) compared with no uterotonic agents (moderate certainty).

1 finding from 1 review

Prophylactic use of ergot alkaloids in the third stage of labour 2018 · Cochrane Headline outcomes only
RR 2.53 [1.34, 4.78]
1 study · 1429 participants
Moderate

Intravenous/intramuscular ergot alkaloids vs no uterotonic agents

Mean blood loss (mL) visual estimation · women in the third stage of labour

1 finding from 1 review

Prophylactic use of ergot alkaloids in the third stage of labour 2018 · Cochrane Headline outcomes only
no estimate extracted
2 studies · 2429 participants
Moderate

Intravenous/intramuscular ergot alkaloids vs no uterotonic agents

Maternal blood loss of 500 mL or greater · women in the third stage of labour

Intravenous/intramuscular ergot alkaloids may leads to lower estimated or measured blood loss of at least 500 mL visual estimation compared with no uterotonic agents (low certainty).

1 finding from 1 review

Prophylactic use of ergot alkaloids in the third stage of labour 2018 · Cochrane Headline outcomes only
RR 0.41 [0.22, 0.75]
4 studies · 3419 participants
Low