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What do systematic reviews say?

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Evidence found and GRADE certainty

9 questions · 18 findings · 1 reviews · Headline outcomes only

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No studies found 10 · 55.6%GRADE not reported 0 · 0%Very low 7 · 38.9%Low 1 · 5.6%Moderate 0 · 0%High 0 · 0%

Intratympanic plus systemic corticosteroids (combined therapy) vs systemic corticosteroids alone

Change in hearing threshold determined by PTA Range 0 dB to 140 dB Negative values represent lowering and positive values represent raising of the hearing threshold. A lower hearing threshold represents hearing improvement. Â · sudden sensorineural hearing loss

Intratympanic plus systemic corticosteroids (combined therapy) showed no clear difference in change in hearing threshold determined by PTA Range 0 dB to 140 dB… compared with systemic corticosteroids alone (low certainty).

2 findings from 1 review

Intratympanic plus systemic corticosteroids (combined therapy) vs systemic corticosteroids alone

Proportion of patients whose hearing is improved · sudden sensorineural hearing loss

It is very uncertain whether intratympanic plus systemic corticosteroids (combined therapy) changes proportion of patients whose hearing is improved compared with systemic corticosteroids alone (very low certainty).

2 findings from 1 review

Intratympanic plus systemic corticosteroids (combined therapy) vs systemic corticosteroids alone

Final hearing threshold determined by PTA (a lower value represents better hearing) · sudden sensorineural hearing loss

It is very uncertain whether intratympanic plus systemic corticosteroids (combined therapy) changes final hearing threshold determined by PTA A lower value represents… compared with systemic corticosteroids alone (very low certainty).

2 findings from 1 review

Intratympanic plus systemic corticosteroids (combined therapy) vs systemic corticosteroids alone

Adverse eventsb · sudden sensorineural hearing loss

The review found no eligible studies for this question.

2 findings from 1 review

Intratympanic plus systemic corticosteroids (combined therapy) vs systemic corticosteroids alone

Persistent tympanic membrane perforation · sudden sensorineural hearing loss
2 findings from 1 review

Intratympanic plus systemic corticosteroids (combined therapy) vs systemic corticosteroids alone

Vertigo/dizziness: timing not reported · sudden sensorineural hearing loss

The review found no eligible studies for this question.

2 findings from 1 review

Intratympanic plus systemic corticosteroids (combined therapy) vs systemic corticosteroids alone

Vertigo/dizziness: at the time of injection · sudden sensorineural hearing loss
2 findings from 1 review

Intratympanic plus systemic corticosteroids (combined therapy) vs systemic corticosteroids alone

Ear pain: timing not reported · sudden sensorineural hearing loss

The review found no eligible studies for this question.

2 findings from 1 review

Intratympanic plus systemic corticosteroids (combined therapy) vs systemic corticosteroids alone

Ear pain: at the time of injection · sudden sensorineural hearing loss
2 findings from 1 review