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Evidence found and GRADE certainty

3,024 questions · 3,338 findings · 330 reviews

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No studies found 735 · 22%GRADE not reported 282 · 8.4%Very low 962 · 28.8%Low 870 · 26.1%Moderate 384 · 11.5%High 105 · 3.1%

Pregabalin vs placebo

Treatment‐related adverse effects · adults and children with sickle cell disease experiencing neuropathic pain

It is very uncertain whether summary of findings ‐ Pharmacological intervention (pregabalin) changes treatment‐related adverse effects compared with placebo (very low certainty).

1 finding from 1 review

Psychological intervention with or without other rehabilitation vs control (usual care/other rehabilitation)

Total mortalityDeaths · patients with coronary heart disease

Psychological intervention with or without other rehabilitation showed no clear difference in total mortalityDeaths compared with control (usual care/other rehabilitation) (moderate certainty).

1 finding from 1 review

Psychological intervention with or without other rehabilitation vs control (usual care/other rehabilitation)

Cardiac mortalityDeaths · patients with coronary heart disease

Psychological intervention with or without other rehabilitation may leads to lower cardiac mortalityDeaths compared with control (usual care/other rehabilitation) (low certainty).

1 finding from 1 review

Psychological intervention with or without other rehabilitation vs control (usual care/other rehabilitation)

Non‐fatal MI · patients with coronary heart disease

Psychological intervention with or without other rehabilitation showed no clear difference in non‐fatal MI compared with control (usual care/other rehabilitation) (low certainty).

1 finding from 1 review

Psychological intervention with or without other rehabilitation vs control (usual care/other rehabilitation)

Revascularisation (CABG and PCI combined) · patients with coronary heart disease

Psychological intervention with or without other rehabilitation showed no clear difference in revascularisation (CABG and PCI combined) compared with control (usual care/other rehabilitation) (moderate certainty).

1 finding from 1 review

Summary of findings table (subcomparison 5): chemotherapy or targeted therapy agent(s) plus control intervention vs control intervention

Overall survival · palliative participants with AC of the esophagus

Summary of findings table (subcomparison 5): chemotherapy or… leads to lower overall survival compared with control intervention alone (high certainty).

1 finding from 1 review

Summary of findings table (subcomparison 5): chemotherapy or targeted therapy agent(s) plus control intervention vs control intervention

Progression‐free survival · palliative participants with AC of the esophagus

It is very uncertain whether summary of findings table (subcomparison 5): chemotherapy or… changes progression‐free survival compared with control intervention alone (very low certainty).

1 finding from 1 review

Summary of findings table (subcomparison 5): chemotherapy or targeted therapy agent(s) plus control intervention vs control intervention

Toxicity · palliative participants with AC of the esophagus

It is very uncertain whether summary of findings table (subcomparison 5): chemotherapy or… changes toxicity compared with control intervention alone (very low certainty).

1 finding from 1 review

Summary of findings table (subcomparison 5): chemotherapy or targeted therapy agent(s) plus control intervention vs control intervention

Overall survival · palliative participants with SCC of the esophagus

Summary of findings table (subcomparison 6): chemotherapy or… leads to lower overall survival compared with control intervention alone (high certainty).

1 finding from 1 review

Summary of findings table (subcomparison 5): chemotherapy or targeted therapy agent(s) plus control intervention vs control intervention

Progression‐free survival · palliative participants with SCC of the esophagus

It is very uncertain whether summary of findings table (subcomparison 6): chemotherapy or… changes progression‐free survival compared with control intervention alone (very low certainty).

1 finding from 1 review