Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

3,024 questions · 3,338 findings · 330 reviews

No studies found 735 · 22%GRADE not reported 282 · 8.4%Very low 962 · 28.8%Low 870 · 26.1%Moderate 384 · 11.5%High 105 · 3.1%

Summary of findings table (subcomparison 4): targeted therapy agent plus control intervention vs control intervention

Progression‐free survival · palliative participants with esophageal and GE‐junction carcinoma

Summary of findings table (subcomparison 4): targeted therapy agent… probably leads to lower progression‐free survival compared with control intervention alone (moderate certainty).

1 finding from 1 review

Summary of findings table (subcomparison 4): targeted therapy agent plus control intervention vs control intervention

Toxicity · palliative participants with esophageal and GE‐junction carcinoma

It is very uncertain whether summary of findings table (subcomparison 4): targeted therapy agent… changes toxicity compared with control intervention alone (very low certainty).

1 finding from 1 review

Summary of findings table (subcomparison 5): chemotherapy or targeted therapy agent(s) plus control intervention vs control intervention

Overall survival · palliative participants with esophageal and GE‐junction carcinoma

Summary of findings table: chemotherapy or targeted therapy agent(s)… leads to lower overall survival compared with control intervention alone (high certainty).

1 finding from 1 review

Summary of findings table (subcomparison 5): chemotherapy or targeted therapy agent(s) plus control intervention vs control intervention

Progression‐free survival · palliative participants with esophageal and GE‐junction carcinoma

Summary of findings table: chemotherapy or targeted therapy agent(s)… probably leads to lower progression‐free survival compared with control intervention alone (moderate certainty).

1 finding from 1 review

Summary of findings table (subcomparison 5): chemotherapy or targeted therapy agent(s) plus control intervention vs control intervention

Toxicity · palliative participants with esophageal and GE‐junction carcinoma

It is very uncertain whether summary of findings table: chemotherapy or targeted therapy agent(s)… changes toxicity compared with control intervention alone (very low certainty).

1 finding from 1 review

Psychosocial interventions vs treatment

Point abstinence (number of participants who were abstinent at the end of the treatment) · adults with stimulant use disorder

Summary of findings table ‐ Any psychosocial intervention showed no clear difference in point abstinence, end of treatment compared with treatment (low certainty).

1 finding from 1 review

Psychosocial interventions vs treatment

Number of continuously abstinent women ‐ total · stopping or reducing alcohol consumption during pregnancy

Summary of findings table ‐ Any psychosocial intervention may leads to higher number of continuously abstinent women ‐ total compared with treatment (low certainty).

1 finding from 1 review

Psychosocial interventions vs treatment

Number of women who completed treatment ‐ total · stopping or reducing alcohol consumption during pregnancy

Summary of findings table ‐ Any psychosocial intervention showed no clear difference in number of women who completed treatment ‐ total compared with treatment (moderate certainty).

1 finding from 1 review

Assistive technology for vision improvement interventions vs usual care or attention control

Number of people sustaining one or more fall‐related fractures · Older people living in the community

It is very uncertain whether assistive technology for vision improvement interventions changes number of people who experienced 1 or more fall‐related fractures compared with usual care or attention control (very low certainty).

1 finding from 1 review