Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

3,024 questions · 3,338 findings · 330 reviews

No studies found 735 · 22%GRADE not reported 282 · 8.4%Very low 962 · 28.8%Low 870 · 26.1%Moderate 384 · 11.5%High 105 · 3.1%

Lay health worker‐ vs enhanced usual care

Clinical symptoms ‐ alcohol use (1 to 6 months post intervention) · adult patients with alcohol dependence

It is very uncertain whether lay health worker‐led interventions changes clinical symptoms ‐ alcohol use (1 to 6 months post intervention) compared with enhanced usual care (very low certainty).

1 finding from 1 review

Lay health worker‐ vs enhanced usual care

Clinical symptoms ‐ depression (1 to 6 months post intervention) · adult patients with alcohol dependence

It is very uncertain whether lay health worker‐led interventions changes clinical symptoms ‐ depression (1 to 6 months post intervention) compared with enhanced usual care (very low certainty).

1 finding from 1 review

Lay health worker‐ vs enhanced usual care

Functional impairment · adult patients with alcohol dependence

It is very uncertain whether lay health worker‐led interventions changes functional impairment (1 to 6 months post intervention) compared with enhanced usual care (very low certainty).

1 finding from 1 review

Oral hygiene interventions (mechanical plaque removal): knowledge-based, behavioural, or skills training for people with ID or their carers vs Usual care, no care, or a similar alternative intervention

Any unintended (positive or negative) effects of the interventions · People with intellectual disabilities (ID), living at home, in day care, in hospital or in a residential care setting; all levels of ID as…
1 finding from 1 review
  • Adverse/unintended effects addressed narratively: 10 of 34 studies investigated or reported negative unintended or adverse effects (e.g. difficulty with the electric or 3-headed toothbrushes, being frightened by the…
    10 studies
    GRADE not reported

Interventions for involving patients in decision‐making about their health care vs usual care

Psychiatric symptoms Brief Psychiatric Rating Scale (BPRS; Overall 1988): 16 items with 7‐item Likert scale ('not present' to 'extremely severe') measured 6 months after intervention (Yamaguchi 2017). · patients with mental health disorders
1 finding from 1 review

Interventions for involving patients in decision‐making about their health care vs usual care

Depression (6 months or more) MADRS measured 6 months after intervention (Aljumah 2015). PHQ‐9 measured 6 months after intervention (LeBlanc 2015). QIDS‐J measured 6 months after intervention (Aoki 2019a). Hospital Anxiety and Depression Scale (HA... · patients with mental health disorders
1 finding from 1 review

Interventions for involving patients in decision‐making about their health care vs usual care

Participation (SDM‐specific‐reported outcomes, immediately after intervention) Combined Outcome Measure for Risk Communication and Treatment Decision‐making Effectiveness (COMRADE; Edwards 2003) measured immediately after decision‐making (Aoki 201... · patients with mental health disorders
1 finding from 1 review

Intervention vs control

Selective bowel decontamination versus inactive control · people undergoing liver transplantation

It is very uncertain whether intervention changes selective bowel decontamination versus inactive control compared with control (very low certainty).

2 findings from 1 review

Intervention vs control

Granulocyte‐colony stimulating factor (G‐CSF) versus placebo · people undergoing liver transplantation

It is very uncertain whether intervention changes granulocyte‐colony stimulating factor (G‐CSF) versus placebo compared with control (very low certainty).

2 findings from 1 review

Intervention vs control

Selective bowel decontamination versus prebiotics with probiotics · people undergoing liver transplantation
2 findings from 1 review

Intervention vs control

Selective bowel decontamination versus prebiotics · people undergoing liver transplantation
2 findings from 1 review