Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

6 questions · 6 findings · 2 reviews

No studies found 0 · 0%GRADE not reported 0 · 0%Very low 3 · 50%Low 0 · 0%Moderate 3 · 50%High 0 · 0%

Summary of findings: insulin detemir vs NPH insulin

AEs other than hypoglycaemia (1) SAE (2) Overall AE (3) AE leading to discontinuation

Insulin detemir showed no clear difference in AEs other than hypoglycaemia (1) SAE (2) Overall AE (3) AE leading… compared with NPH insulin (moderate certainty).

1 finding from 1 review

Summary of findings: insulin detemir vs insulin glargine

Severe nocturnal hypoglycaemia (n/N) Definition: severe hypoglycaemia occurring 00:01‐05:59 (Davies 2014) or 23:00‐07:00 (BEGIN Young)

It is very uncertain whether summary of findings: insulin detemir changes severe nocturnal hypoglycaemia (n/N) Definition: severe… compared with insulin glargine (very low certainty).

1 finding from 1 review

Summary of findings: insulin detemir vs NPH insulin

Severe nocturnal hypoglycaemia (n/N) Definition: severe hypoglycaemia occurring 00:01‐05:59 (Davies 2014) or 23:00‐07:00 (BEGIN Young)

Summary of findings: insulin detemir showed no clear difference in severe nocturnal hypoglycaemia (n/N) Definition: severe… compared with NPH insulin (moderate certainty).

1 finding from 1 review