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Evidence found and GRADE certainty

167 questions · 179 findings · 14 reviews

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No studies found 42 · 23.5%GRADE not reported 23 · 12.8%Very low 35 · 19.6%Low 50 · 27.9%Moderate 24 · 13.4%High 5 · 2.8%

Summary of findings: insulin detemir vs Insulin glargin (control)

Percentage of participants having at least one severe hypoglycaemic event · patients with type 2 diabetes mellitus

Insulin detemir (intervention) showed no clear difference in percentage of participants having at least one severe hypoglycaemic… compared with insulin glargin (control) (low certainty).

1 finding from 1 review

Summary of findings: insulin detemir vs Insulin glargin (control)

Percentage of participants having at least one hypoglycaemic event · patients with type 2 diabetes mellitus

Insulin detemir (intervention) showed no clear difference in percentage of participants having at least one hypoglycaemic event compared with insulin glargin (control) (low certainty).

1 finding from 1 review

Summary of findings: insulin detemir vs Insulin glargin (control)

Injection‐site reaction Rates of patients · patients with type 2 diabetes mellitus

Insulin detemir (intervention) may leads to higher percentage of participants having at least one injection site reaction compared with insulin glargin (control) (low certainty).

1 finding from 1 review

Pre‐mixed insulin (70 NPH/30 REG) vs self‐mixed split dose insulin (Different insulin regimens with similar insulin types used within the regimen)

Macrosomia · pregnant women with pre‐existing diabetes

It is very uncertain whether pre‐mixed insulin (70 NPH/30 REG) changes macrosomia compared with self‐mixed split dose insulin (Different insulin regimens with… (very low certainty).

1 finding from 1 review

Pre‐mixed insulin (70 NPH/30 REG) vs self‐mixed split dose insulin (Different insulin regimens with similar insulin types used within the regimen)

Caesarean section 4 · pregnant women with pre‐existing diabetes

It is very uncertain whether pre‐mixed insulin (70 NPH/30 REG) changes caesarean section 4 compared with self‐mixed split dose insulin (Different insulin regimens with… (very low certainty).

1 finding from 1 review

Insulin injected with a Novolin pen vs insulin injected with a needle or syringe (Different insulin regimens with similar insulin types used within the regimen)

Macrosomia · pregnant women with pre‐existing diabetes

It is very uncertain whether insulin injected with a Novolin pen changes macrosomia compared with insulin injected with a needle or syringe (Different insulin… (very low certainty).

1 finding from 1 review

Insulin injected with a Novolin pen vs insulin injected with a needle or syringe (Different insulin regimens with similar insulin types used within the regimen)

Caesarean section 4 · pregnant women with pre‐existing diabetes

It is very uncertain whether insulin injected with a Novolin pen changes caesarean section 4 compared with insulin injected with a needle or syringe (Different insulin… (very low certainty).

1 finding from 1 review