Findings

What do systematic reviews say?

9 questions · 10 findings · 2 reviews

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No studies found 0 · 0%GRADE not reported 1 · 10%Very low 5 · 50%Low 4 · 40%Moderate 0 · 0%High 0 · 0%

Inhaled NO vs placebo

Pain resolution · people with SCD

1 finding from 1 review

Inhaled nitric oxide for treating pain crises in people with sickle cell disease 2022 · Cochrane Headline outcomes only
no estimate extracted
1 study · 150 participants
Low

Inhaled NO vs placebo

Frequency of pain crises in the · people with SCD

Inhaled nitric oxide showed no clear difference in frequency of pain crises in the compared with placebo (low certainty).

2 findings from 1 review

Inhaled nitric oxide for treating pain crises in people with sickle cell disease 2022 · Cochrane Headline outcomes only
RR 0.73 [0.31, 1.71]
1 study · 150 participants
Low
Inhaled nitric oxide for treating pain crises in people with sickle cell disease 2022 · Cochrane Headline outcomes only
RR 0.53 [0.25, 1.11]
1 study · 150 participants
Low

Inhaled NO vs placebo

Adverse events · people with SCD

1 finding from 1 review

Inhaled nitric oxide for treating pain crises in people with sickle cell disease 2022 · Cochrane Headline outcomes only
no estimate extracted
1 study · 150 participants
Low

Inhaled NO vs placebo or conventional therapy

Long‐term mortality · all infants and children with congenital heart disease having postoperative management of pulmonary hypertension

1 finding from 1 review

Inhaled nitric oxide for the postoperative management of pulmonary hypertension in infants and children with… 2014 · Cochrane Headline outcomes only
no estimate extracted
0 studies · 0 participants
GRADE not reported

Inhaled NO vs placebo or conventional therapy

Mortality before hospital discharge · all infants and children with congenital heart disease having postoperative management of pulmonary hypertension

It is very uncertain whether inhaled nitric oxide changes mortality prior to discharge1 compared with placebo or conventional therapy (very low certainty).

1 finding from 1 review

Inhaled nitric oxide for the postoperative management of pulmonary hypertension in infants and children with… 2014 · Cochrane Headline outcomes only
OR 1.67 [0.38, 7.3]
2 studies · 162 participants
Very low

Inhaled NO vs placebo or conventional therapy

Difference in MPAP change score (SE) ‐ Conventional Management4 · all infants and children with congenital heart disease having postoperative management of pulmonary hypertension

1 finding from 1 review

Inhaled nitric oxide for the postoperative management of pulmonary hypertension in infants and children with… 2014 · Cochrane Headline outcomes only
no estimate extracted
2 studies · 4 participants
Very low

Inhaled NO vs placebo or conventional therapy

Difference in MPAP change score (SE) ‐ Placebo4 · all infants and children with congenital heart disease having postoperative management of pulmonary hypertension

1 finding from 1 review

Inhaled nitric oxide for the postoperative management of pulmonary hypertension in infants and children with… 2014 · Cochrane Headline outcomes only
no estimate extracted
1 study · 2 participants
Very low

Inhaled NO vs placebo or conventional therapy

Difference in MAP change score (SE) ‐ Conventional Mangement4 · all infants and children with congenital heart disease having postoperative management of pulmonary hypertension

1 finding from 1 review

Inhaled nitric oxide for the postoperative management of pulmonary hypertension in infants and children with… 2014 · Cochrane Headline outcomes only
no estimate extracted
2 studies · 4 participants
Very low

Inhaled NO vs placebo or conventional therapy

Difference in MAP change score (SE) ‐ Placebo4 · all infants and children with congenital heart disease having postoperative management of pulmonary hypertension

1 finding from 1 review

Inhaled nitric oxide for the postoperative management of pulmonary hypertension in infants and children with… 2014 · Cochrane Headline outcomes only
no estimate extracted
1 study · 2 participants
Very low