Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

55 questions · 55 findings · 9 reviews · Airways

No studies found 3 · 5.5%GRADE not reported 3 · 5.5%Very low 8 · 14.5%Low 21 · 38.2%Moderate 20 · 36.4%High 0 · 0%

IV + inhaled beta agonist vs inhaled beta‐agonist

Clinical Failure (children with a severe to moderate overall clinical assessment score at two hours) · patients with acute asthma

IV + inhaled beta agonist probably leads to lower clinical Failure (children with a severe to moderate overall… compared with inhaled beta‐agonist (moderate certainty).

1 finding from 1 review

Summary of findings ‐ Inhaled mannitol vs placebo

Hospitalisations Number of participants experiencing one of more hospitalisations. · people with bronchiectasis

Inhaled mannitol showed no clear difference in hospitalisations Number of participants experiencing one of more… compared with placebo (moderate certainty).

1 finding from 1 review

Summary of findings ‐ Inhaled mannitol vs placebo

SGRQ Total SGRQ (Total) Score. Scale from: 0 to 100. Lower score indicates better quality of life. · people with bronchiectasis

Inhaled mannitol showed no clear difference in health‐related quality of life measured on the SGRQ Scale from 0 to… compared with placebo (moderate certainty).

1 finding from 1 review

Inhaled corticosteroids vs placebo

Pseudomonas aeruginosa (P aeruginosa) colonisation · people with bronchiectasis

Inhaled corticosteroids showed no clear difference in pseudomonas aeruginosa (P aeruginosa) colonisation compared with placebo (low certainty).

1 finding from 1 review