Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

249 questions · 258 findings · 25 reviews

No studies found 52 · 20.2%GRADE not reported 8 · 3.1%Very low 71 · 27.5%Low 56 · 21.7%Moderate 61 · 23.6%High 10 · 3.9%

Inhaled NO vs placebo

Frequency of pain crises in the · people with SCD

Inhaled nitric oxide showed no clear difference in frequency of pain crises in the compared with placebo (low certainty).

2 findings from 1 review

Inhaled NO vs placebo or conventional therapy

Mortality before hospital discharge · all infants and children with congenital heart disease having postoperative management of pulmonary hypertension

It is very uncertain whether inhaled nitric oxide changes mortality prior to discharge1 compared with placebo or conventional therapy (very low certainty).

1 finding from 1 review