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What do systematic reviews say?

7 questions · 7 findings · 1 reviews · Pregnancy and Childbirth

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No studies found 0 · 0%GRADE not reported 4 · 57.1%Very low 3 · 42.9%Low 0 · 0%Moderate 0 · 0%High 0 · 0%

Metformin vs insulin

Hypoglycaemia · women with type 2 diabetes

It is very uncertain whether infant outcomes: oral anti‐diabetic agent (metformin) changes hypoglycaemia compared with insulin (very low certainty).

1 finding from 1 review

Oral anti‐diabetic agents for women with established diabetes/impaired glucose tolerance or previous gestational… 2017 · Cochrane Headline outcomes only
RR 0.34 [0.18, 0.62]
3 studies · 241 participants
Very low

Metformin vs insulin

Health status and well‐being – neonatal morbidity and mortality combined · women with type 2 diabetes

1 finding from 1 review

Oral anti‐diabetic agents for women with established diabetes/impaired glucose tolerance or previous gestational… 2017 · Cochrane Headline outcomes only
no estimate extracted
0 studies · 0 participants
GRADE not reported

Metformin vs insulin

Neurosensory disability · women with type 2 diabetes

1 finding from 1 review

Oral anti‐diabetic agents for women with established diabetes/impaired glucose tolerance or previous gestational… 2017 · Cochrane Headline outcomes only
no estimate extracted
0 studies · 0 participants
GRADE not reported

Metformin vs insulin

Childhood/adulthood adiposity · women with type 2 diabetes

1 finding from 1 review

Oral anti‐diabetic agents for women with established diabetes/impaired glucose tolerance or previous gestational… 2017 · Cochrane Headline outcomes only
no estimate extracted
0 studies · 0 participants
GRADE not reported

Metformin vs insulin

Childhood/adulthood diabetes · women with type 2 diabetes

1 finding from 1 review

Oral anti‐diabetic agents for women with established diabetes/impaired glucose tolerance or previous gestational… 2017 · Cochrane Headline outcomes only
no estimate extracted
0 studies · 0 participants
GRADE not reported

Metformin vs insulin

Large‐for‐gestational age · women with type 2 diabetes

It is very uncertain whether infant outcomes: oral anti‐diabetic agent (metformin) changes large‐for‐gestational age compared with insulin (very low certainty).

1 finding from 1 review

Oral anti‐diabetic agents for women with established diabetes/impaired glucose tolerance or previous gestational… 2017 · Cochrane Headline outcomes only
RR 1.12 [0.73, 1.72]
1 study · 206 participants
Very low

Metformin vs insulin

Perinatal mortality · women with type 2 diabetes

1 finding from 1 review

Oral anti‐diabetic agents for women with established diabetes/impaired glucose tolerance or previous gestational… 2017 · Cochrane Headline outcomes only
no estimate extracted
2 studies · 220 participants
Very low